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Yersinia pestis--etiologic agent of plague
TLDR
The present understanding of the history, etiology, epidemiology, clinical aspects, and public health issues of plague is updated. Expand
Genome Sequence of Yersinia pestis KIM
TLDR
The KIM genome sequence was compared with that of Y. pestis CO92, biovar Orientalis, revealing homologous sequences but a remarkable amount of genome rearrangement for strains so closely related, in a manner consistent with present knowledge of replication and recombination. Expand
Iron acquisition in plague: modular logic in enzymatic biogenesis of yersiniabactin by Yersinia pestis.
TLDR
Sequence analysis of yersiniabactin biosynthetic regions reveals a strategy for siderophore production using a mixed polyketide synthase/nonribosomal peptide synthetase complex formed between HMWP1 and H MWP2 (encoded by irp1 and irp2). Expand
Role of the Yersinia pestis Hemin Storage (hms) Locus in the Transmission of Plague by Fleas
TLDR
Yersinia pestis hms mutants established long-term infection of the flea's midgut but failed to colonize the proventriculus, the site in the foregut where blockage normally develops, leading to a change in blood-feeding behavior and to efficient transmission of plague. Expand
HmsP, a putative phosphodiesterase, and HmsT, a putative diguanylate cyclase, control Hms‐dependent biofilm formation in Yersinia pestis
TLDR
It is proposed that HmsT and HmsP together control the amount of biofilm produced in Y. pestis and may be a critical factor in controlling the temperature‐dependent expression of the Hms biofilm. Expand
Environmental modulation of gene expression and pathogenesis in Yersinia.
TLDR
The yersiniae are a useful model for understanding how environmental modulation of gene expression allows pathogens to inhabit a wide range of niches and how adaptive gene expression may promote successful pathogenesis. Expand
The Yfe system of Yersinia pestis transports iron and manganese and is required for full virulence of plague
TLDR
The data suggest that the Yfe and Ybt systems may function effectively to accumulate iron during different stages of the infectious process of bubonic plague. Expand
Systematic analysis of cyclic di‐GMP signalling enzymes and their role in biofilm formation and virulence in Yersinia pestis
TLDR
The results show that a key event in the evolution of Y. pestis from the ancestral Yersinia pseudotuberculosis was a significant reduction in the complexity of its c‐di‐GMP signalling network likely resulting from the different disease cycles of these human pathogens. Expand
YbtA, an AraC‐type regulator of the Yersinia pestis pesticin/yersiniabactin receptor
TLDR
Insertional inactivation of ybt A resulted in decreased synthesis of Psn and proteins encoded by the irp2 operon as well as decreased expression from the psn::lacZ promoter fusion, indicating that Ybt’A is a transcriptional activator for psn and the putative siderophore biosynthetic genes. Expand
YbtP and YbtQ: two ABC transporters required for iron uptake in Yersinia pestis
TLDR
A ybtP mutant showed reduced iron accumulation and was avirulent in mice by a subcutaneous route of infection that mimics flea transmission of bubonic plague, indicating that YbtP and YbtQ are needed for iron uptake. Expand
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