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Yersinia pestis--etiologic agent of plague
The present understanding of the history, etiology, epidemiology, clinical aspects, and public health issues of plague is updated.
Genome Sequence of Yersinia pestis KIM
The KIM genome sequence was compared with that of Y. pestis CO92, biovar Orientalis, revealing homologous sequences but a remarkable amount of genome rearrangement for strains so closely related, in a manner consistent with present knowledge of replication and recombination.
Iron acquisition in plague: modular logic in enzymatic biogenesis of yersiniabactin by Yersinia pestis.
Systematic analysis of cyclic di‐GMP signalling enzymes and their role in biofilm formation and virulence in Yersinia pestis
The results show that a key event in the evolution of Y. pestis from the ancestral Yersinia pseudotuberculosis was a significant reduction in the complexity of its c‐di‐GMP signalling network likely resulting from the different disease cycles of these human pathogens.
HmsP, a putative phosphodiesterase, and HmsT, a putative diguanylate cyclase, control Hms‐dependent biofilm formation in Yersinia pestis
- O. Kirillina, Jacqueline D. Fetherston, A. G. Bobrov, J. Abney, R. Perry
- BiologyMolecular microbiology
- 1 October 2004
It is proposed that HmsT and HmsP together control the amount of biofilm produced in Y. pestis and may be a critical factor in controlling the temperature‐dependent expression of the Hms biofilm.
Environmental modulation of gene expression and pathogenesis in Yersinia.
The Yfe system of Yersinia pestis transports iron and manganese and is required for full virulence of plague
The data suggest that the Yfe and Ybt systems may function effectively to accumulate iron during different stages of the infectious process of bubonic plague.
The pigmentation locus of Yersinia pestis KIM6+ is flanked by an insertion sequence and includes the structural genes for pesticin sensitivity and HMWP2
It is shown that a clone, pSDR498, from the pgm locus of KIM6+ restores pesticin sensitivity and the iron‐regulated expression of three polypeptides, 240 kDa, 190 k da, and 68 kDa in size, to Pgm− cells, and a survey of pgm− strains indicates that 97% have also deleted the sequences encoding the 190 kDa protein and pesticide sensitivity.
The phosphodiesterase activity of the HmsP EAL domain is required for negative regulation of biofilm formation in Yersinia pestis.
YbtA, an AraC‐type regulator of the Yersinia pestis pesticin/yersiniabactin receptor
Insertional inactivation of ybt A resulted in decreased synthesis of Psn and proteins encoded by the irp2 operon as well as decreased expression from the psn::lacZ promoter fusion, indicating that Ybt’A is a transcriptional activator for psn and the putative siderophore biosynthetic genes.