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Yersinia pestis--etiologic agent of plague.
Plague is a widespread zoonotic disease that is caused by Yersinia pestis and has had devastating effects on the human population throughout history. Disappearance of the disease is unlikely due to… Expand
Genome sequence of Yersinia pestis KIM.
We present the complete genome sequence of Yersinia pestis KIM, the etiologic agent of bubonic and pneumonic plague. The strain KIM, biovar Mediaevalis, is associated with the second pandemic,… Expand
Role of the Yersinia pestis Hemin Storage (hms) Locus in the Transmission of Plague by Fleas
Yersinia pestis, the cause of bubonic plague, is transmitted by the bites of infected fleas. Biological transmission of plague depends on blockage of the foregut of the flea by a mass of plague… Expand
Iron acquisition in plague: modular logic in enzymatic biogenesis of yersiniabactin by Yersinia pestis.
BACKGROUND Virulence in the pathogenic bacterium Yersinia pestis, causative agent of bubonic plague, has been correlated with the biosynthesis and transport of an iron-chelating siderophore,… Expand
The Yfe system of Yersinia pestis transports iron and manganese and is required for full virulence of plague
Iron acquisition in Yersinia pestis is fundamental to the success of plague pathogenesis. We have previously identified an ≈5.6 kb region (yfe) of Y. pestis genomic DNA, capable of restoring… Expand
HmsP, a putative phosphodiesterase, and HmsT, a putative diguanylate cyclase, control Hms‐dependent biofilm formation in Yersinia pestis
- O. Kirillina, J. Fetherston, A. Bobrov, J. Abney, R. Perry
- Biology, Medicine
- Molecular microbiology
- 1 October 2004
The Hms+ phenotype of Yersinia pestis promotes the binding of haemin or Congo red (CR) to the cell surface at temperatures below 34°C. We previously demonstrated that temperature regulation of the… Expand
Environmental modulation of gene expression and pathogenesis in Yersinia.
The yersiniae are a useful model for understanding how environmental modulation of gene expression allows pathogens to inhabit a wide range of niches. This review follows the enteropathogenic… Expand
Systematic analysis of cyclic di‐GMP signalling enzymes and their role in biofilm formation and virulence in Yersinia pestis
Cyclic di‐GMP (c‐di‐GMP) is a signalling molecule that governs the transition between planktonic and biofilm states. Previously, we showed that the diguanylate cyclase HmsT and the putative c‐di‐GMP… Expand
YbtA, an AraC‐type regulator of the Yersinia pestis pesticin/yersiniabactin receptor
The pesticin receptor (Psn) of Yersinia pestis confers sensitivity to the bacteriocin, pesticin, and is an integral component of an inorganic‐iron‐transport system that functions at 37°C. Synthesis… Expand
YbtP and YbtQ: two ABC transporters required for iron uptake in Yersinia pestis
Yersinia pestis, the causative agent of plague, makes a siderophore termed yersiniabactin (Ybt), which it uses to obtain iron during growth at 37°C. The genes required for the synthesis and… Expand