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Hereditary differences in the expression of the human glutathione transferase active on trans-stilbene oxide are due to a gene deletion.
Glutathione transferase (GT; EC 2.5.1.18) mRNA levels were measured in human liver samples by using mouse and human cDNA clones that encode class-mu and class-alpha GT. Although all the RNA samplesExpand
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Enhanced DNA repair, immune function and reduced toxicity of C-MED-100, a novel aqueous extract from Uncaria tomentosa.
Female W/Fu rats were gavaged daily with a water-soluble extract (C-MED-100) of Uncaria tomentosa supplied commercially by CampaMed at the doses of 0, 5, 10, 20, 40 and 80 mg/kg for 8 consecutiveExpand
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Treatment of chemotherapy-induced leukopenia in a rat model with aqueous extract from Uncaria tomentosa.
The Uncaria tomentosa water extracts (C-Med-100) depleted of indole alkaloids (< 0.05%, w/w) have been shown to induce apoptosis and inhibit proliferation in tumor cells in vitro and to enhance DNAExpand
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Toxicity of metabolites produced by the "Alternaria".
The presence of toxin-producing fungi in foodstuffs and other agricultural commodities is well established (1-3). The Alternaria, Aspergilli, Fusaria and Penicillia have been repeatedly implicated asExpand
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An extract of Uncaria tomentosa inhibiting cell division and NF-kappa B activity without inducing cell death.
Previous reports have demonstrated that extracts of the plant Uncaria tomentosa inhibit tumor cell proliferation and inflammatory responses. We have confirmed that C-Med 100, a hot water extract ofExpand
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A water soluble extract from Uncaria tomentosa (Cat's Claw) is a potent enhancer of DNA repair in primary organ cultures of human skin
Cat's Claw (Uncaria tomentosa) water extracts, essentially free of oxindole alkaloids, have been shown to possess a broad spectrum of biological activity including DNA repair enhancement andExpand
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Isoenzyme(s) of glutathione transferase (class Mu) as a marker for the susceptibility to lung cancer: a follow up study.
Glutathione transferase are divided into three classes: Alpha, Mu and Pi. Isoenzyme(s) from one of these classes, class Mu, is dominantly inherited and can be determined by activity measurementsExpand
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Newly discovered anti-inflammatory properties of the benzamides and nicotinamides
Our laboratory has concentrated on the possible regulation the benzamides and nicotinamides may have on the processes of DNA repair and apoptosis. Recent reports [14-16] have suggested that bothExpand
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Reduced level of serum thiols in patients with a diagnosis of active disease.
Oxidative stress, or the production of oxygen-centered free radicals, has been hypothesized as the major source of DNA damage that in turn can lead to altered genetic expression, disease, and agingExpand
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A glutathione transferase in human leukocytes as a marker for the susceptibility to lung cancer.
Leukocyte isozyme(s) of glutathione transferase (GT-tSBO) has been shown to be dominantly inherited. The frequency of the phenotypes of this isozyme in bronchial carcinoma and control patientsExpand
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