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Hereditary differences in the expression of the human glutathione transferase active on trans-stilbene oxide are due to a gene deletion.
Glutathione transferase (GT; EC mRNA levels were measured in human liver samples by using mouse and human cDNA clones that encode class-mu and class-alpha GT. Although all the RNA samplesExpand
Enhanced DNA repair, immune function and reduced toxicity of C-MED-100, a novel aqueous extract from Uncaria tomentosa.
Female W/Fu rats were gavaged daily with a water-soluble extract of Uncaria tomentosa supplied commercially by CampaMed at the doses of 0, 5, 10, 20, 40 and 80 mg/kg for 8 consecutive weeks and no acute or chronic toxicity signs were observed symptomatically. Expand
Toxicity of metabolites produced by the "Alternaria".
The Alternaria are plant pathogens and thus can contaminate food through field infection as well as through storage, and have been studied to only a small extent. Expand
Treatment of chemotherapy-induced leukopenia in a rat model with aqueous extract from Uncaria tomentosa.
Data showing enhanced effects on DNA repair and immune cell proliferative response support a general immune enhancement and the recovery by C-Med-100 treatment was a more natural process than Neupogen because all fractions of white blood cells were proportionally increased while Ne upogen mainly elevated the neutrophil cells. Expand
Isoenzyme(s) of glutathione transferase (class Mu) as a marker for the susceptibility to lung cancer: a follow up study.
It is concluded that the gene expressing class Mu isoenzymes may be a host determinant of genetic susceptibility to lung cancer among smokers. Expand
An extract of Uncaria tomentosa inhibiting cell division and NF-kappa B activity without inducing cell death.
It is confirmed that C-Med 100, a hot water extract of this plant, inhibits tumor cell proliferation albeit with variable efficiency and it is proposed that retarded cell cycle progression caused the inhibition of proliferation. Expand
A water soluble extract from Uncaria tomentosa (Cat's Claw) is a potent enhancer of DNA repair in primary organ cultures of human skin
C‐Med‐100, a Cat's Claw water extract, is the only documented natural source of components that can up‐regulate simultaneously both DNA repair and antiinflammation, and its ability to modulate DNA repair in human skin organ cultures was undertaken. Expand
A glutathione transferase in human leukocytes as a marker for the susceptibility to lung cancer.
It was concluded that the gene expressing this isozyme(s) may be a host genetic determinant of susceptibility to lung cancer in smokers. Expand
A reduced capacity for unscheduled DNA synthesis in lymphocytes from individuals exposed to propylene oxide and ethylene oxide.
Another closely related epoxide, PO, is found to have caused inhibition of UDS after occupational exposure, which is the first report of the genotoxic effects of PO in man. Expand
Biologic markers in ethylene oxide-exposed workers and controls.
Significant effects of low-level EtO exposure, independent of smoking history, near or below 1 ppm on multiple biomarkers are demonstrated and suggests that the current OSHA standard may not be adequately protective. Expand