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Reconstruction and Simulation of Neocortical Microcircuitry
A first-draft digital reconstruction of the microcircuitry of somatosensory cortex of juvenile rat is presented, finding a spectrum of network states with a sharp transition from synchronous to asynchronous activity, modulated by physiological mechanisms. Expand
A synaptic organizing principle for cortical neuronal groups
A synaptic organizing principle is discovered that groups neurons in a manner that is common across animals and hence, independent of individual experiences that is speculated to be prescribed Lego-like building blocks of perception. Expand
Ephaptic coupling of cortical neurons
It is found that endogenous brain activity can causally affect neural function through field effects under physiological conditions, and extracellular fields induced ephaptically mediated changes in the somatic membrane potential that were less than 0.5 mV under subthreshold conditions. Expand
A Biophysically Detailed Model of Neocortical Local Field Potentials Predicts the Critical Role of Active Membrane Currents
It is found that, depending on a number of factors, the LFP reflects local and cross-layer processing, and active currents dominate the generation of LFPs, not synaptic ones. Expand
Frequency‐dependent disynaptic inhibition in the pyramidal network: a ubiquitous pathway in the developing rat neocortex
It is shown that frequency‐dependent disynaptic inhibition (FDDI) is a generic circuit motif that is present in all neocortical areas the authors investigated and suggests that the basic construction of neocorticals synaptic pathways follows principles that are independent of modality or hierarchical order within the neocortex. Expand
Cliques of Neurons Bound into Cavities Provide a Missing Link between Structure and Function
It is proposed that the brain processes stimuli by forming increasingly complex functional cliques and cavities that evolve in a stereotypical sequence toward peak complexity. Expand
Brief Bursts Self-Inhibit and Correlate the Pyramidal Network
A multi-cell patch clamp study reveals the summation properties of frequency-dependent disynaptic inhibition between neocortical pyramidal cells and shows how brief bursts of activity in a few cellsExpand
A computer-assisted multi-electrode patch-clamp system.
  • R. Perin, H. Markram
  • Computer Science, Medicine
  • Journal of visualized experiments : JoVE
  • 18 October 2013
This work developed a computer-assisted system which centralizes all the controls necessary for a multi-electrode patch-clamp experiment in a single interface, a commercially available wireless gamepad, while displaying experiment related information and guidance cues on the computer screen. Expand
Cell type- and activity-dependent extracellular correlates of intracellular spiking.
It is found that spiking of excitatory neurons can significantly impact the local field potential (LFP) at frequencies as low as 20 Hz, and the common assertion that the LFP acts as proxy for synaptic activity is questioned. Expand
On the Structure of Cortical Microcircuits Inferred from Small Sample Sizes
This work shows that data from rat cortex is consistent with a network in which the likelihood of a connection between neurons depends on spatial distance and on nonspatial, asymmetric clustering, and develops a connectivity measure that successfully classifies networks even when estimated locally with a few neurons at a time. Expand