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Efficacy of intravenous phenytoin in the treatment of status epilepticus: Kinetics of central nervous system penetration
Intravenous phenytoin rapidly enters the central nervous system and results in prompt and effective treatment of status epilepticus without suppressing higher cortical function or cardiorespiratory centers. Expand
Rapid gas-liquid chromatographic determination of carbamazepine in plasma.
A rapid, sensitive method is described for the quantitative determination of carbamazepine in plasma and the derivatives formed by the reaction of the drug and internal standard with dimethylformamide dimethyl acetal are stable for at least 17 h. Expand
Valproic acid and plasma levels of phenobarbital
Data suggest that phenobarbital metabolism is inhibited by therapeutic plasma levels of valproic acid, which is associated with decreased renal excretion in normal cats and patients with epilepsy. Expand
In vivo uptake of valproic acid into brain
The small volume of distribution, low brain:plasma ratios and rapid clearance from brain indicate that VPA is not significantly bound in cerebral cortex after a single dose. Expand
Pharmaceutical and clinical analysis by tandem mass spectrometry.
A new technique for determining the structures of all the metabolites of a particular drug has also been developed, which is possible to identify in a single sample all molecular ions which contain substructures characteristic of the parent drug. Expand
Rapid, simultaneous GLC determination of phenobarbital, primidone, and diphenylhydantoin.
A rapid method is described for the simultaneous determination of phenobarbital, primidone, and diphenylhydantoin, which gives greater sensitivity and reproducibility than the short methods now in use, maintains the efficiency of much longer techniques, and takes only 45 min. Expand
Steady‐state kinetics of valproic acid in epileptic patients
Constant levels are maintained in individual patients, but there is substantial intersubject variation. Expand
Flame-ionization and electron-capture GLC determination of 1-(2,6-dimethylphenoxy)-2-aminopropane in plasma.
A sensitive flame-ionization GLC method is described for the determination of the new anticonvulsant, 1-(2,6-dimethylphenoxy)-2-aminopropane, in plasma. The method is compared with a simultaneouslyExpand