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Mosaicism in Vacuolating Cytotoxin Alleles of Helicobacter pylori
- J. Atherton, P. Cao, R. Peek, M. Tummuru, M. Blaser, T. Cover
- Biology, Medicine
- The Journal of Biological Chemistry
- 28 July 1995
Approximately 50% of Helicobacter pylori strains produce a cytotoxin, encoded by vacA, that induces vacuolation of eukaryotic cells. Analysis of a clinically isolated tox strain (Tx30a) indicated… Expand
Helicobacter pylori and gastrointestinal tract adenocarcinomas
Although gastric adenocarcinoma is associated with the presence of Helicobacter pylori in the stomach, only a small fraction of colonized individuals develop this common malignancy. H. pylori strain… Expand
Helicobacter pylori and Gastric Cancer: Factors That Modulate Disease Risk
SUMMARY Helicobacter pylori is a gastric pathogen that colonizes approximately 50% of the world's population. Infection with H. pylori causes chronic inflammation and significantly increases the risk… Expand
Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach.
To determine whether infection with a Helicobacter pylori strain possessing cagA is associated with an increased risk of development of adenocarcinoma of the stomach, we used a nested case-control… Expand
Clinical and pathological importance of heterogeneity in vacA, the vacuolating cytotoxin gene of Helicobacter pylori.
BACKGROUND & AIMS vacA encodes the vacuolating cytotoxin of Helicobacter pylori and exhibits marked variation in signal sequence and midgene coding regions. The implications for gastroduodenal… Expand
Differential activation of mitogen-activated protein kinases in AGS gastric epithelial cells by cag+ and cag- Helicobacter pylori.
- S. Keates, A. C. Keates, M. Warny, R. Peek, P. Murray, C. Kelly
- Medicine, Biology
- Journal of immunology
- 15 November 1999
The aim of this study was to determine whether Helicobacter pylori activates mitogen-activated protein (MAP) kinases in gastric epithelial cells. Infection of AGS cells with an H. pylori cag+ strain… Expand
Activation of β-catenin by carcinogenic Helicobacter pylori
Persistent gastritis induced by Helicobacter pylori is the strongest known risk factor for adenocarcinoma of the distal stomach, yet only a fraction of colonized persons ever develop gastric cancer.… Expand
Inflammation and intestinal metaplasia of the gastric cardia: the role of gastroesophageal reflux and H. pylori infection.
BACKGROUND & AIMS Whether inflammation of the cardia indicates gastroesophageal reflux disease (GERD) and/or is a manifestation of pangastritis caused by Helicobacter pylori infection is unknown. The… Expand
Helicobacter infection and gastric neoplasia
Chronic gastritis induced by Helicobacter pylori is the strongest known risk factor for adenocarcinoma of the distal stomach, yet only a minority of people who harbour this organism ever develop… Expand
Helicobacter pylori: gastric cancer and beyond
Helicobacter pylori is the dominant species of the human gastric microbiome, and colonization causes a persistent inflammatory response. H. pylori-induced gastritis is the strongest singular risk… Expand