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Derivation of pluripotent epiblast stem cells from mammalian embryos
Although the first mouse embryonic stem (ES) cell lines were derived 25 years ago using feeder-layer-based blastocyst cultures, subsequent efforts to extend the approach to other mammals, including… Expand
Activin/Nodal and FGF pathways cooperate to maintain pluripotency of human embryonic stem cells
Maintenance of pluripotency is crucial to the mammalian embryo's ability to generate the extra-embryonic and embryonic tissues that are needed for intrauterine survival and foetal development. The… Expand
Clonal analysis of epiblast fate during germ layer formation in the mouse embryo.
The fate of cells in the epiblast at prestreak and early primitive streak stages has been studied by injecting horseradish peroxidase (HRP) into single cells in situ of 6.7-day mouse embryos and… Expand
Dlx5 regulates regional development of the branchial arches and sensory capsules.
We report the generation and analysis of mice homozygous for a targeted deletion of the Dlx5 homeobox gene. Dlx5 mutant mice have multiple defects in craniofacial structures, including their ears,… Expand
Role of the Dlx homeobox genes in proximodistal patterning of the branchial arches: mutations of Dlx-1, Dlx-2, and Dlx-1 and -2 alter morphogenesis of proximal skeletal and soft tissue structures…
The Dlx homeobox gene family is expressed in a complex pattern within the embryonic craniofacial ectoderm and ectomesenchyme. A previous study established that Dlx-2 is essential for development of… Expand
Activin/Nodal signalling maintains pluripotency by controlling Nanog expression
The pluripotent status of embryonic stem cells (ESCs) confers upon them the capacity to differentiate into the three primary germ layers, ectoderm, mesoderm and endoderm, from which all the cells of… Expand
Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor
SINCE the discovery that epidermal growth factor (EGF) can accelerate opening of the eyelids1, the EGF receptor (EGF-R) has been extensively studied and is now considered to be a prototype tyrosine… Expand
Null mutation of Dlx-2 results in abnormal morphogenesis of proximal first and second branchial arch derivatives and abnormal differentiation in the forebrain.
Genetic analysis of the development and evolution of the vertebrate head is at a primitive stage. Many homeo box genes, including the Distal-less family, are potential regulators of head development.… Expand
Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells.
The endocrine pancreas is organized into clusters of cells called islets of Langerhans comprising four well-defined cell types: alpha beta, delta and PP cells. While recent genetic studies indicate… Expand
Generation of human vascular smooth muscle subtypes provides insight into embryological origin-dependent disease susceptibility
- Christine Cheung, A. S. Bernardo, M. Trotter, R. Pedersen, Sanjay Sinha
- Biology, Medicine
- Nature Biotechnology
- 4 January 2012
Heterogeneity of embryological origins is a hallmark of vascular smooth muscle cells (SMCs) and may influence the development of vascular disease. Differentiation of human pluripotent stem cells… Expand