• Publications
  • Influence
An integrated stress response regulates amino acid metabolism and resistance to oxidative stress.
Eukaryotic cells respond to unfolded proteins in their endoplasmic reticulum (ER stress), amino acid starvation, or oxidants by phosphorylating the alpha subunit of translation initiation factor 2Expand
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  • Open Access
Assessing Gene Significance from cDNA Microarray Expression Data via Mixed Models
The determination of a list of differentially expressed genes is a basic objective in many cDNA microarray experiments. We present a statistical approach that allows direct control over theExpand
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  • Open Access
The human decatenation checkpoint
Chromatid catenation is actively monitored in human cells, with progression from G2 to mitosis being inhibited when chromatids are insufficiently decatenated. Mitotic delay was quantified in normalExpand
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  • Open Access
DNA damage and cell cycle checkpoints
  • W. Kaufmann, R. Paules
  • Biology, Medicine
  • FASEB journal : official publication of the…
  • 1 February 1996
DNA is prone to numerous forms of damage that can injure cells and impair fitness. Cells have evolved an array of mechanisms to repair these injuries. Proliferating cells are especially vulnerable toExpand
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Oxidative stress and cell cycle checkpoint function.
Oxidative stress and the damage that results from it have been implicated in a wide number of disease processes including atherosclerosis, autoimmune disorders, neuronal degeneration, and cancer.Expand
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Gene expression analysis reveals chemical-specific profiles.
The application of gene expression profiling technology to examine multiple genes and signaling pathways simultaneously promises a significant advance in understanding toxic mechanisms to ultimatelyExpand
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Gene expression profiling of rat livers reveals indicators of potential adverse effects.
This study tested the hypothesis that gene expression profiling can reveal indicators of subtle injury to the liver induced by a low dose of a substance that does not cause overt toxicity as definedExpand
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  • Open Access
DNA double strand breaks activate a multi-functional genetic program in developing lymphocytes
DNA double-strand breaks are generated by genotoxic agents and by cellular endonucleases as intermediates of several important physiological processes. The cellular response to genotoxic DNA breaksExpand
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Blood gene expression signatures predict exposure levels
To respond to potential adverse exposures properly, health care providers need accurate indicators of exposure levels. The indicators are particularly important in the case of acetaminophen (APAP)Expand
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An ATR- and Chk1-Dependent S Checkpoint Inhibits Replicon Initiation following UVC-Induced DNA Damage
ABSTRACT Inhibition of replicon initiation is a stereotypic DNA damage response mediated through S checkpoint mechanisms not yet fully understood. Studies were undertaken to elucidate the function ofExpand
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