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Molecular and genetic analyses of Tic20 homologues in Arabidopsis thaliana chloroplasts.
Analysis of Tic20 sequences from many species indicated that they are phylogenetically unrelated to mitochondrial Tim17-22-23 proteins, and that they form two evolutionarily conserved subgroups [characterized by psTic20/atTic 20-I/IV (Group 1) and atTIC20-II/V (Group 2)].
Analysis of Transposon Insertion Mutants Highlights the Diversity of Mechanisms Underlying Male Progamic Development in Arabidopsis
Gene sequences disrupted in seth insertions suggest essential functions for putative SETH proteins in diverse processes including protein anchoring, cell wall biosynthesis, signaling, and metabolism.
Epidemiology of β‐thalassaemia in Western India: mapping the frequencies and mutations in sub‐regions of Maharashtra and Gujarat
The first attempt to provide an accurate estimate of the frequencies of β‐thalassaemia and the expected annual births of homozygous children in different districts of Maharashtra and Gujarat in Western India as well as to determine the molecular heterogeneity in different sub‐regions in these states are provided.
Synthesis of chiral pharmaceutical intermediates by biocatalysis
Chiral intermediates were prepared by biocatalytic processes for the chemical synthesis of four pharmaceutical drug candidates. These include: (i) the microbial reduction of 3,5-dioxo-6-(benzyloxy)
Transformation of Nε-CBZ-l-lysine to CBZ-l-oxylysine using l-amino acid oxidase from Providencia alcalifaciens and l-2-hydroxy-isocaproate dehydrogenase from Lactobacillus confusus
Providencia alcalifaciens (SC9036, ATCC 13159) was a good microbial substitute for the snake venom oxidase and also provided catalase (H2O2:H2 O2 oxidoreductase EC from Candida boidinii.
Biocatalysis in the pharmaceutical and biotechnology industries
Nitrilases and Nitrile Hydratases R. DiCosimo Biocatalytic Deracemization: Dynamic Resolution, Stereoinversion, Enantioconvergent Processes and Cyclic Deracemization Y.Simeo, W. Kroutil, and K. Faber
Purification and Cloning of a Ketoreductase used for the Preparation of Chiral Alcohols
The synthesis of the leading candidate compound in an anticancer program required (S)-2-chloro-1-(3-chlorophenyl)-ethanol as an intermediate. Other possible candidate compounds used analogues of the
Nucleotide binding and dimerization at the chloroplast pre-protein import receptor, atToc33, are not essential in vivo but do increase import efficiency.
Neither nucleotide binding nor dimerization at atToc33 is essential for chloroplast import (in plants that continue to express the other TOC receptors in native form), although both processes do increase import efficiency.
Enzymatic Preparation of an (S)-Amino Acid from a Racemic Amino Acid
The (S)-amino acid, (S)-2-amino-3-(6-o-tolylpyridin-3-yl)propanoic acid (3), is a key intermediate needed for synthesis of an antidiabetic drug candidate. Three enzymatic routes to 3 were explored.
Enzymic hydrolysis of 7‐xylosyltaxanes by xylosidase from Moraxella sp.
A bacterial strain isolated from soil and identified as a Moraxella sp.