Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation
- K. Cosby, Kristine S Partovi, M. Gladwin
- Biology, MedicineNature Network Boston
- 1 December 2003
It is suggested that nitrite represents a major bioavailable pool of NO, and a new physiological function for hemoglobin as a nitrite reductase is described, potentially contributing to hypoxic vasodilation.
Hydrogen sulfide mediates the vasoactivity of garlic
- G. Benavides, G. Squadrito, D. Kraus
- Biology, ChemistryProceedings of the National Academy of Sciences
- 13 November 2007
It is shown that human RBCs convert garlic-derived organic polysulfides into hydrogen sulfide (H2S), an endogenous cardioprotective vascular cell signaling molecule, strongly supporting the hypothesis that H2S mediates the vasoactivity of garlic.
Cytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liver.
- Mark R. Duranski, James J. M. Greer, D. Lefer
- BiologyJournal of Clinical Investigation
- 2 May 2005
The results suggest that nitrite is a biological storage reserve of NO subserving a critical function in tissue protection from ischemic injury and an unexpected and novel therapy for diseases such as myocardial infarction, organ preservation and transplantation, and shock states.
The emerging biology of the nitrite anion
- M. Gladwin, A. Schechter, J. Lundberg
- BiologyNature Chemical Biology
- 1 November 2005
Nitrite has now been proposed to play an important physiological role in signaling, blood flow regulation and hypoxic nitric oxide homeostasis. A recent two-day symposium at the US National…
Enzymatic function of hemoglobin as a nitrite reductase that produces NO under allosteric control.
- Zhi Huang, S. Shiva, M. Gladwin
- Chemistry, BiologyJournal of Clinical Investigation
- 1 August 2005
Hypoxic vasodilation is a fundamental, highly conserved physiological response that requires oxygen and/or pH sensing coupled to vasodilation. While this process was first characterized more than 80…
Oxygen radical inhibition of nitric oxide-dependent vascular function in sickle cell disease
- M. Aslan, T. M. Ryan, B. Freeman
- BiologyProceedings of the National Academy of Sciences…
- 18 December 2001
Data reveal that episodes of intrahepatic hypoxia-reoxygenation associated with SCD can induce the release of XO into the circulation from the liver.
Nitrated Fatty Acids: Endogenous Anti-inflammatory Signaling Mediators*
- T. Cui, F. Schopfer, Y. Chen
- Biology, ChemistryJournal of Biological Chemistry
- 24 November 2006
Observations indicate that nitroalkenes such as LNO2 and OA-NO2, derived from reactions of unsaturated fatty acids and oxides of nitrogen, are a class of endogenous anti-inflammatory mediators.
Catalytic generation of N2O3 by the concerted nitrite reductase and anhydrase activity of hemoglobin.
- S. Basu, Rozalina Grubina, D. Kim-Shapiro
- Chemistry, BiologyNature Chemical Biology
- 1 December 2007
A fundamental heme globin- and Nitrite-catalyzed chemical reaction pathway to N2O3, NO and S-nitrosothiol that could form the basis of in vivo nitrite-dependent signaling is revealed.
Hydrogen sulfide mediates vasoactivity in an O2-dependent manner.
- J. Koenitzer, T. Isbell, D. Kraus
- BiologyAmerican Journal of Physiology. Heart and…
- 1 April 2007
In rat aorta, H( 2)S concentrations that mediate rapid contraction at high O(2) levels cause rapid relaxation at lower physiological O(1) levels, suggesting that it may be a putative vasoactive oxidation product that mediates constriction that modulates vascular tone in vivo.
Cellular Localization, Oligomerization, and Membrane Association of the Hereditary Spastic Paraplegia 3A (SPG3A) Protein Atlastin*
- P. Zhu, Andrew D. Patterson, C. Blackstone
- BiologyJournal of Biological Chemistry
- 5 December 2003
Findings indicate that the SPG3A protein atlastin-1 is a multimeric integral membrane GTPase that may be involved in Golgi membrane dynamics or vesicle trafficking.
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