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In Vitro Activities of Posaconazole, Fluconazole, Itraconazole, Voriconazole, and Amphotericin B against a Large Collection of Clinically Important Molds and Yeasts
TLDR
Posaconazole exhibited potent antifungal activity against a wide variety of clinically important fungal pathogens and was frequently more active than other azoles and amphotericin B.
Frequency of Isolation of Staphylococcus lugdunensis in Consecutive Urine Cultures and Relationship to Urinary Tract Infection
TLDR
Five hundred isolates of coagulase-negative staphylococci (CoNS) were recovered from 4,652 consecutive urine specimens submitted for culture to the Mayo Clinic Microbiology Laboratory and six out of 500 isolates were identified as S. lugdunensis.
Emergence of quinolone resistance among viridans group streptococci isolated from the oropharynx of neutropenic peripheral blood stem cell transplant patients receiving quinolone antimicrobial
TLDR
Quinolone-resistant viridans group streptococci are frequently found in the oropharynx of neutropenic patients after a brief (median, 8 days) exposure to gatifloxacin or moxiflOxacin.
Advanced Human Immunodeficiency Virus Disease in Botswana Following Successful Antiretroviral Therapy Rollout: Incidence of and Temporal Trends in Cryptococcal Meningitis
TLDR
Despite excellent ART coverage in Botswana, there is still a substantial burden of advanced HIV, with 2013-2014 incidence of CM comparable to pre-ART era rates in South Africa, suggesting that a key population of individuals is developing advanced disease and associated opportunistic infections due to a failure to effectively engage in care.
Combinations of cefoxitin plus other β-lactams are synergistic in vitro against community associated methicillin-resistant Staphylococcus aureus
TLDR
In vitro studies demonstrate that oxacillin minimal inhibitory concentrations of methicillin-resistant S. aureus (MRSA) strains USA300 and 400 decrease in the presence of cefoxitin while combined with a variety of β-lactams enhances their activity against CA-MRSA strains in vitro.
Isolation and restriction endonuclease analysis of mycobacterial DNA.
TLDR
A method for the isolation of DNA from mycobacteria propagated in vitro is described that utilizes organic solvents to extract lipoidal components from the outer membrane, and digestion with a protease (nagarse) and lysozyme to penetrate the cell wall, indicating that this approach can be used for identifyingMycobacterial species.
Unreliable Extended-Spectrum β-Lactamase Detection in the Presence of Plasmid-Mediated AmpC in Escherichia coli Clinical Isolates
TLDR
The results indicate poor performance of currently employed ESBL confirmatory methods in the setting of concomitant pAmpC in Escherichia coli, raising concern over currently employed breakpoints.
Pharmacokinetics of cefpirome following intravenous and intramuscular administration in goats.
TLDR
The study was undertaken on pharmacokinetics of cefpirome following intravenous and intramuscular administration in the goat in order to understand species difference.
Cefonicid, a long acting cephalosporin: in vitro activity compared with three cephalosporins and gentamicin.
TLDR
Cefonicid promises to be a useful addition to the range of cephalosporins already available and showed a broader spectrum than cefazolin but was not as active as ceftazidime or gentamicin.
Accessory Genomes Drive Independent Spread of Carbapenem-Resistant Klebsiella pneumoniae Clonal Groups 258 and 307
TLDR
CG307 is widely circulating CRKp clone in the Houston region with the potential to transfer major resistance determinants to other non-CG258 CRK p lineages, and provides major insights into the mechanism of epidemic spread of CRKP.