4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1
- M. Trevisani, J. Siemens, P. Geppetti
- BiologyProceedings of the National Academy of Sciences
- 14 August 2007
It is reported that recombinant or native TRPA1 channels are activated by 4-hydroxy-2-nonenal (HNE), an endogenous α,β-unsaturated aldehyde that is produced when reactive oxygen species peroxidate membrane phospholipids in response to tissue injury, inflammation, and oxidative stress.
Cigarette smoke-induced neurogenic inflammation is mediated by alpha,beta-unsaturated aldehydes and the TRPA1 receptor in rodents.
- E. André, B. Campi, R. Patacchini
- BiologyJournal of Clinical Investigation
- 1 July 2008
Cigarette smoke (CS) inhalation causes an early inflammatory response in rodent airways by stimulating capsaicin-sensitive sensory neurons that express transient receptor potential cation channel,…
Tachykinin receptors and tachykinin receptor antagonists.
- C. Maggi, R. Patacchini, P. Rovero, A. Giachetti
- BiologyJournal of autonomic pharmacology
- 1 February 1993
Oxaliplatin elicits mechanical and cold allodynia in rodents via TRPA1 receptor stimulation
- R. Nassini, M. Gees, P. Geppetti
- BiologyPain
- 1 July 2011
Hydrogen sulfide causes vanilloid receptor 1‐mediated neurogenic inflammation in the airways
- M. Trevisani, R. Patacchini, S. Harrison
- Biology, MedicineBritish Journal of Pharmacology
- 1 August 2005
The results provide the first pharmacological evidence that H2S provokes tachykinin‐mediated neurogenic inflammatory responses in guinea‐pig airways, and that this effect is mediated by stimulation of TRPV1 receptors on sensory nerves endings.
TRPA1 and TRPV4 mediate paclitaxel-induced peripheral neuropathy in mice via a glutathione-sensitive mechanism
- S. Materazzi, C. Fusi, R. Nassini
- BiologyPflügers Archiv: European Journal of Physiology
- 19 January 2012
Paclitaxel via oxygen radical formation targets TRPA1 and TRPV4, and both channels are key for the delayed development of mechanical allodynia, which is, however, entirely dependent onTRPA1.
Transient receptor potential ankyrin receptor 1 is a novel target for pro‐tussive agents
- E. André, R. Gatti, P. Geppetti
- Biology, MedicineBritish Journal of Pharmacology
- 1 November 2009
This work investigated whether TRPA1 agonists provoke cough in guinea pigs and whether TRPV1 antagonists inhibit this response and found no evidence that either of these mechanisms are inhibited.
Novel therapeutic strategy to prevent chemotherapy-induced persistent sensory neuropathy by TRPA1 blockade.
- G. Trevisan, S. Materazzi, R. Nassini
- BiologyCancer Research
- 11 March 2013
A key role for early activation/sensitization of TRPA1 by oxidative stress by-products in producing CIPN is highlighted and prevention strategies for CIPn in patients are suggested through the use of early, short-term treatments with TRPA 1 antagonists.
Acetaminophen, via its reactive metabolite N-acetyl-p-benzo-quinoneimine and transient receptor potential ankyrin-1 stimulation, causes neurogenic inflammation in the airways and other tissues in…
- R. Nassini, S. Materazzi, P. Geppetti
- Biology, MedicineThe FASEB Journal
- 1 December 2010
It is hypothesized that APAP, via NAPQI, stimulates TRPA1, thus causing airway neurogenic inflammation, which may contribute to the risk of COPD and asthma associated with therapeutic APAP use.
Newly discovered tachykinins raise new questions about their peripheral roles and the tachykinin nomenclature.
- R. Patacchini, A. Lecci, P. Holzer, C. Maggi
- Biology, ChemistryTIPS - Trends in Pharmacological Sciences
- 2004
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