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4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1
It is reported that recombinant or native TRPA1 channels are activated by 4-hydroxy-2-nonenal (HNE), an endogenous α,β-unsaturated aldehyde that is produced when reactive oxygen species peroxidate membrane phospholipids in response to tissue injury, inflammation, and oxidative stress. Expand
Tachykinin receptors and tachykinin receptor antagonists.
Cigarette smoke-induced neurogenic inflammation is mediated by alpha,beta-unsaturated aldehydes and the TRPA1 receptor in rodents.
Cigarette smoke (CS) inhalation causes an early inflammatory response in rodent airways by stimulating capsaicin-sensitive sensory neurons that express transient receptor potential cation channel,Expand
Oxaliplatin elicits mechanical and cold allodynia in rodents via TRPA1 receptor stimulation
It is hypothesized that the transient receptor potential ankyrin 1 (TRPA1), a cation channel activated by oxidative stress and cold temperature, contributes to mechanical and cold hypersensitivity caused by oxaliplatin and cisplatin. Expand
Hydrogen sulfide causes vanilloid receptor 1‐mediated neurogenic inflammation in the airways
The results provide the first pharmacological evidence that H2S provokes tachykinin‐mediated neurogenic inflammatory responses in guinea‐pig airways, and that this effect is mediated by stimulation of TRPV1 receptors on sensory nerves endings. Expand
TRPA1 and TRPV4 mediate paclitaxel-induced peripheral neuropathy in mice via a glutathione-sensitive mechanism
Paclitaxel via oxygen radical formation targets TRPA1 and TRPV4, and both channels are key for the delayed development of mechanical allodynia, which is, however, entirely dependent onTRPA1. Expand
Transient receptor potential ankyrin receptor 1 is a novel target for pro‐tussive agents
This work investigated whether TRPA1 agonists provoke cough in guinea pigs and whether TRPV1 antagonists inhibit this response and found no evidence that either of these mechanisms are inhibited. Expand
Newly discovered tachykinins raise new questions about their peripheral roles and the tachykinin nomenclature.
The tachykinin family has recently been extended by the discovery of a third tachykinin gene encoding previously unknown mammalian tachykinins (hemokinin 1, endokinin A and endokinin B) that have aExpand
Alpha,beta-unsaturated aldehydes in cigarette smoke release inflammatory mediators from human macrophages.
It is demonstrated that alpha,beta-unsaturated aldehydes are major mediators of cigarette smoke-induced macrophage activation, and suggested that they might contribute to pulmonary inflammation associated with cigarette smoke. Expand
Hydrogen sulfide (H2S) stimulates capsaicin‐sensitive primary afferent neurons in the rat urinary bladder
Results provide pharmacological evidence that H2S stimulates capsaicin‐sensitive primary afferent nerve terminals, from which tachykinins are released to produce the observed contraction by activating NK1 and NK2 receptors. Expand