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Rab11 regulates recycling through the pericentriolar recycling endosome
- O. Ullrich, S. Reinsch, S. Urbé, M. Zerial, R. Parton
- BiologyThe Journal of cell biology
- 2 November 1996
A novel role for rab11 in controlling traffic through the recycling endosome is suggested after functional studies showed that the early steps of uptake and recycling for transferrin were not affected by overexpression of rab11 proteins.
Localization of phosphatidylinositol 3‐phosphate in yeast and mammalian cells
- D. Gillooly, Isabel C. Morrow, H. Stenmark
- Biology, Computer ScienceThe EMBO journal
- 1 September 2000
PI(3)P follows a conserved intralumenal degradation pathway, and its generation, accessibility and turnover are likely to play a crucial role in defining the early endosomes and the subsequent steps leading to multivesicular endosome formation.
The multiple faces of caveolae
The apparently diverse functions of caveolae, including mechanosensing and lipid regulation, might be linked to their ability to respond to plasma membrane changes, a property that is dependent on their specialized lipid composition and biophysical properties.
Inhibition of rab5 GTPase activity stimulates membrane fusion in endocytosis.
- H. Stenmark, R. Parton, O. Steele‐Mortimer, A. Lütcke, J. Gruenberg, M. Zerial
- BiologyThe EMBO journal
- 1 March 1994
The opposite effects of the rab5 Q79L and S34N mutants suggest that rab5:GTP is required prior to membrane fusion, whereas GTP hydrolysis by rab5 occurs after membrane fusion and functions to inactivate the protein.
A lipid associated with the antiphospholipid syndrome regulates endosome structure and function
- Toshihide Kobayashi, E. Stang, K. Fang, P. Moerloose, R. Parton, J. Gruenberg
- 12 March 1998
This work shows that these internal membranes contain large amounts of a unique lipid, and thus form specialized domains within endosomes, involved in sorting the multifunctional receptor for insulin-like growth factor 2 and ligands bearing mannose-6-phosphate, in particular lysosomal enzymes.
GPI-anchored proteins are delivered to recycling endosomes via a distinct cdc42-regulated, clathrin-independent pinocytic pathway.
EEA1, an Early Endosome-Associated Protein.
It is proposed that EEA1 is required for vesicular transport of proteins through early endosomes and that its finger motifs are required for this activity.
APPL Proteins Link Rab5 to Nuclear Signal Transduction via an Endosomal Compartment
Localization of low molecular weight GTP binding proteins to exocytic and endocytic compartments
Biogenesis of phagolysosomes proceeds through a sequential series of interactions with the endocytic apparatus
Observations suggest that phagolysosome formation is a highly dynamic process that involves the gradual and regulated acquisition of markers from endocytic organelles.