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Species- and cell type-specific interactions between CD47 and human SIRPalpha.
CD47 on red blood cells (RBCs) reportedly signals "self" by binding SIRPalpha on phagocytes, at least in mice. Such interactions across and within species, from mouse to human, are not yet clear andExpand
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Protein 4.2 is critical to CD47-membrane skeleton attachment in human red cells.
The reduction in expression of the integral membrane protein CD47 in human red blood cells (RBCs) deficient in protein 4.2 suggests that protein 4.2 may mediate a linkage of CD47 to the membraneExpand
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Sortase A as a novel molecular "stapler" for sequence-specific protein conjugation.
The Sortase family of transpeptidase enzymes catalyzes sequence-specific ligation of proteins to the cell wall of Gram-positive bacteria. Here, we describe the application of recombinantExpand
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Biochemical and molecular properties of lithium-sensitive myo-inositol monophosphatase.
Myo-inositol monophosphatase is a pivotal enzyme of the inositol second messenger system which is specifically inhibited by therapeutic levels of lithium salts, implicating inhibition of this enzymeExpand
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Targeted worm micelles.
Giant and stable worm micelles formed from poly(ethylene glycol) (PEG)-based diblock copolymer amphiphiles have the potential advantage compared to smaller assemblies for delivery of a large quantityExpand
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The inositol phospholipids: a stereochemical view of biological activity.
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Protein-Protein Fusion Catalyzed by Sortase A
Chimeric proteins boast widespread use in areas ranging from cell biology to drug delivery. Post-translational protein fusion using the bacterial transpeptidase sortase A provides an attractiveExpand
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Properties and expression of human tartrate‐resistant acid phosphatase isoform 5a by monocyte‐derived cells
Human serum tartrate‐resistant acid phosphatase exists as two enzyme isoforms (TRACP 5a and 5b), derived by differential, post‐translational processing of a common gene product. Serum TRACP 5b isExpand
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Controllable protein phase separation and modular recruitment to form responsive membraneless organelles
Many intrinsically disordered proteins self-assemble into liquid droplets that function as membraneless organelles. Because of their biological importance and ability to colocalize molecules at highExpand
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Myo-Inositol Monophosphatase: Diverse Effects of Lithium, Carbamazepine, and Valproate
The therapeutic molecular sites of action for the mood-stabilizing medications are unknown. Myo-inositol monophosphatase (E.C. is a major enzyme of the inositol signaling system that hasExpand
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