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Performance measures in three rounds of the English bowel cancer screening pilot
Objectives To compare performance measures across all three rounds of the English bowel cancer screening faecal occult blood test pilot and their relation to social deprivation and ethnicity. MethodsExpand
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The UK colorectal cancer screening pilot: results of the second round of screening in England
An evaluation of the second round of faecal occult blood (FOB) screening in the English site of the UK Colorectal Cancer Screening Pilot (comprising the Bowel Cancer Screening Pilot based in Rugby,Expand
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Extent of initial corneal injury as the mechanistic basis for ocular irritation: key findings and recommendations for the development of alternative assays.
Currently, there are no recognized alternative tests to eliminate the use of animals in ocular irritation testing. A major reason no replacement alternatives have been developed is that the currentExpand
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Increased hyaline droplet formation in male rats exposed to decalin is dependent on the presence of alpha 2u-globulin.
A peculiar decalin-induced male rat nephropathy associated with the altered renal handling of filtered protein appears limited to the accumulation of the protein, alpha 2u-globulin. Several strainsExpand
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Pathology of Ocular Irritation with Bleaching Agents in the Rabbit Low-Volume Eye Test
Despite differences in the processes leading to tissue damage, the ocular irritation response to various surfactants, two concentrations of an acid and an alkali, and an acetone, alcohol, aromaticExpand
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Light Microscopic Comparison of Surfactant-Induced Eye Irritation in Rabbits and Rats at Three Hours and Recovery/Day 35*1
Limited information exists on the pathologic changes occurring with surfactant-induced ocular irritation in the context of accidental human exposures and animal tests used to assess for suchExpand
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Evaluation of seven in vitro alternatives for ocular safety testing.
Seven in vitro assays were evaluated to determine if any were useful as screening procedures in ocular safety assessment. Seventeen test materials (chemicals, household cleaners, hand soaps,Expand
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Microscopic Changes with Acetic Acid and Sodium Hydroxide in the Rabbit Low-Volume Eye Test
Differences in ocular irritancy have been hypothesized to reflect differences in the extent of initial injury. Although differences in the processes leading to tissue damage may exist, extent ofExpand
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Reducing the number of rabbits in the low-volume eye test.
Although the Draize eye irritation test has provided important and useful information for eye safety assessments, considerable effort has been directed toward refining the assay procedure, reducingExpand
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