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Decapping and Decay of Messenger RNA Occur in Cytoplasmic Processing Bodies
The flux of mRNAs between polysomes and P bodies is defined as a critical aspect of cytoplasmic mRNA metabolism and a possible site for regulation of mRNA degradation.
P bodies and the control of mRNA translation and degradation.
MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies
It is demonstrated that Argonaute proteins — the signature components of the RNA interference (RNAi) effector complex, RISC — localize to mammalian P-bodies and suggested that translation repression by RISC delivers mRNAs to P- bodies, either as a cause or as a consequence of inhibiting protein synthesis.
Eukaryotic stress granules: the ins and outs of translation.
ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure
Endonucleolytic cleavage of eukaryotic mRNAs with stalls in translation elongation
It is shown that yeast mRNAs with stalls in translation elongation are recognized and targeted for endonucleolytic cleavage, referred to as ‘no-go decay’, which provides a mechanism for clearing the cell of stalledtranslation elongation complexes.
A role for the P-body component GW182 in microRNA function
- Jidong Liu, F. Rivas, J. Wohlschlegel, J. Yates, R. Parker, G. Hannon
- BiologyNature Cell Biology
- 13 November 2005
The results support a functional link between cytoplasmic P-bodies and the ability of a microRNA to repress expression of a target mRNA.
Formation and Maturation of Phase-Separated Liquid Droplets by RNA-Binding Proteins.
P bodies promote stress granule assembly in Saccharomyces cerevisiae
It is demonstrated in Saccharomyces cerevisiae that RNA granules with similar protein composition and assembly mechanisms as mammalian stress granules form during glucose deprivation, indicating that P bodies are important sites for decisions of mRNA fate and that stressgranules primarily represent pools of mRNAs stalled in the process of reentry into translation from P bodies.