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The Barley Mlo Gene: A Novel Control Element of Plant Pathogen Resistance
Analysis of mutagen-induced recessive alleles of the barley Mlo locus revealed mutations leading in each case to alterations of the deduced Mlo wild-type amino acid sequence, compatible with a dual negative control function of the Mlo protein in leaf cell death and in the onset of pathogen defense. Expand
Conserved requirement for a plant host cell protein in powdery mildew pathogenesis
A conserved requirement for MLO proteins in powdery mildew pathogenesis in the dicotyledonous plant species Arabidopsis thaliana is demonstrated, suggesting that within the Erysiphales (powdery mildews) the ability to cause disease has been a stable trait throughout phylogenesis. Expand
Autophagy Negatively Regulates Cell Death by Controlling NPR1-Dependent Salicylic Acid Signaling during Senescence and the Innate Immune Response in Arabidopsis[W][OA]
A conserved requirement for salicylic acid (SA) signaling for senescence and immunity-related programmed cell death phenomena in autophagy-defective mutants (atg mutants) is demonstrated and it is shown that autophagic is induced by the SA agonist. Expand
A Glucosinolate Metabolism Pathway in Living Plant Cells Mediates Broad-Spectrum Antifungal Defense
It is proposed that reiterated enzymatic cycles, controlling the generation of toxic molecules and their detoxification, enable the recruitment of glucosinolates in defense responses. Expand
Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses
Findings show that preinvasion perception of plant-derived signals substantially reprograms fungal gene expression and indicate previously unknown functions for particular fungal cell types. Expand
Co-option of a default secretory pathway for plant immune responses
The disease resistance function of the secretory PEN1–SNAP33–VAMP721/722 complex and the pathogen-induced subcellular dynamics of its components are mechanistically reminiscent of immunological synapse formation in vertebrates, enabling execution of immune responses through focal secretion. Expand
Genome Expansion and Gene Loss in Powdery Mildew Fungi Reveal Tradeoffs in Extreme Parasitism
A group of papers analyzes pathogen genomes to find the roots of virulence, opportunism, and life-style determinants in plant pathogens, suggesting that most effectors represent species-specific adaptations. Expand
An Arabidopsis Callose Synthase, GSL5, Is Required for Wound and Papillary Callose Formation Article, publication date, and citation information can be found at
Depletion of callose from papillae in gsl5 plants marginally enhanced the penetration of the grass powdery mildew fungus Blumeria graminis on the nonhost Arabidopsis, providing strong genetic evidence that the GSL genes of higher plants encode proteins that are essential for callose formation. Expand
Molecular Phylogeny and Evolution of the Plant-Specific Seven-Transmembrane MLO Family
A computational analysis of MLO family members based on 31 full-size and 3 partial sequences revealed evidence for concerted evolution of all three cytoplasmic domains with each other and the C-terminal cytopLasmic tail, suggesting interplay of all intracellular domains for MLO function. Expand
SNARE-ware: the role of SNARE-domain proteins in plant biology.
In yeast and animal cells, members of the superfamily of N-ethylmaleimide-sensitive factor adaptor protein receptor (SNARE)-domain-containing proteins are key players in vesicle-associated membraneExpand