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Transgenic Expression of Glud1 (Glutamate Dehydrogenase 1) in Neurons: In Vivo Model of Enhanced Glutamate Release, Altered Synaptic Plasticity, and Selective Neuronal Vulnerability
TLDR
The Tg mice were significantly more resistant than wild-type mice to induction and duration of anesthesia produced by anesthetics that suppress Glu neurotransmission and might be a useful model for the effects of lifelong excess synaptic Glu release on CNS neurons and for age-associated neurodegenerative processes. Expand
Genomic and biochemical approaches in the discovery of mechanisms for selective neuronal vulnerability to oxidative stress
TLDR
Low energy reserves and high intrinsic stress levels are two underlying factors for neuronal selective vulnerability to OS and these mechanisms can be targeted in the future for the protection of vulnerable neurons. Expand
High intrinsic oxidative stress may underlie selective vulnerability of the hippocampal CA1 region.
TLDR
It was found that the CA1 region of hippocampus explants, cultured under normal conditions, had significantly higher superoxide levels and expressed both anti-oxidant genes and genes related to the generation of reactive oxygen species at significantly higher levels than the CA3. Expand
Elevated levels of brain-pathologies associated with neurodegenerative diseases in the methionine sulfoxide reductase A knockout mouse
TLDR
It is suggested that a deficiency in MsrA activity fosters oxidative-stress that is manifested by the accumulation of faulty proteins (via methionine oxidation), deposition of aggregated proteins, and premature brain cell death. Expand
Transcriptomic responses in mouse brain exposed to chronic excess of the neurotransmitter glutamate
TLDR
This is the first study attempting to define neuronal gene expression patterns in response to chronic, endogenous Glu hyperactivity at brain synapses, and patterns observed were characterized by a combination of responses to stress and stimulation of nerve growth, intracellular transport and recovery. Expand
Selective dendrite-targeting of mRNAs of NR1 splice variants without exon 5: identification of a cis-acting sequence and isolation of sequence-binding proteins
TLDR
It is concluded that the 24-base sequence in 5'-UTR of ex5(-) mRNA functioned as a cis-acting, dendrite-targeting element recognized selectively by two microsome proteins. Expand
Ischemic tolerance in an in vivo model of glutamate preconditioning
TLDR
The results suggest that increased proteasome activity and MAP2A synthesis and transport might account for the effectiveness of glutamate preconditioning against ischemia–reperfusion. Expand
3-Acetylpyridine reduces tongue protrusion force but does not abolish lick rhythm in the rat
TLDR
The task of licking water from a force-transducing disk was investigated in water-restricted rats that received systemic administration of 3AP and various changes in lick dynamics may be due to the detrimental effects of 3 AP at the IO, and possibly at the hypoglossal nucleus and other sites. Expand
Immunologic localization and kinetic characterization of a Na+/Ca2+ exchanger in neuronal and non-neuronal cells
TLDR
The kinetics of the Na+/Ca2+ exchanger in primary neurons in culture, in a neuronal hybrid cell line (NCB-20), and in a fibroblast-like cell lines (CV-1) were examined to see whether the level of exchanger activity correlated with the degree of immunostaining produced by the antibodies. Expand
Genome-wide transcriptome profiling of region-specific vulnerability to oxidative stress in the hippocampus.
TLDR
The functional genomics approach has identified in CA1 cells molecular pathways as well as unique genes, such as guanosine deaminase, lipocalin 2, synaptotagmin 4, and latrophilin 2 whose time-dependent induction following the initiation of OS may represent attempts at neurite outgrowth, synaptic recovery, and resistance against OS. Expand
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