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Preoperative radiotherapy for vaccine associated sarcoma in 92 cats.
TLDR
Preoperative irradiation is an effective treatment for cats with vaccine associated sarcoma, especially if complete excision can be accomplished following irradiation, and outcome in cats receiving carboplatin was better than all other treatment groups.
P‐glycoprotein expression in canine lymphoma: A relevant, intermediate model of multidrug resistance
TLDR
Canine lymphoma is a spontaneously arising correlate of human non‐Hodgkin's lymphoma that may complement other in vivo models for investigation of issues related to MDR.
Radiation therapy and surgery for fibrosarcoma in 33 cats.
TLDR
It is found that the presence of tumor cells at the margin of resected tissue after radiation was the only variable which influenced treatment success and the disease free interval in cats with histologically confirmed fibrosarcomas.
Palliative radiotherapy of appendicular osteosarcoma in 95 dogs.
TLDR
Ninety-five dogs with either a presumptive or biopsy confirmed diagnosis of osteosarcoma received palliative radiotherapy using 60Co photons and seventy-three of the 95 dogs experienced pain relief following treatment.
Radiation therapy for incompletely resected canine mast cell tumors.
TLDR
Data presented herein support megavoltage radiation as an effective treatment for canine mast cell neoplasia, and suggest that disease free interval in dogs treated with daily fractions may be longer than that achieved with alternating day fractions.
Treatment of canine appendicular osteosarcoma using cobalt 60 radiation and intraarterial cisplatin.
TLDR
This mode of therapy was well tolerated and may be considered an alternative to amputation or limb-sparing surgical procedures in selected dogs with appendicular osteosarcoma.
Differential effects of mitomycin C and doxorubicin on P-glycoprotein expression.
TLDR
It is demonstrated that MMC and doxorubicin have differential effects on Pgp expression and function, implying that there are at least two independent chemosensitive steps that can alter P-glycoprotein biogenesis: one at the level of mRNA transcription and the other at thelevel of Pgp trafficking.
Effects of Tissue Transglutaminase on Retinoic Acid-induced Cellular Differentiation and Protection against Apoptosis*
TLDR
It was determined that expression of exogenous TGase in cells exhibited enhanced GTP binding and transamidation activities and mimicked the survival advantage imparted by RA, suggesting that TGase may function to ensure cell survival under conditions of differentiation and cell stress.
Augmentation of Tissue Transglutaminase Expression and Activation by Epidermal Growth Factor Inhibit Doxorubicin-induced Apoptosis in Human Breast Cancer Cells*
TLDR
It is indicated for the first time that EGF can induce TGase expression and activation in human breast cancer cells and that this contributes to their oncogenic potential by promoting chemoresistance.
Pharmacokinetic and phase I evaluation of carboplatin in dogs.
TLDR
Dose-independent serum CBDCA pharmacokinetic disposition indicates that detailed investigation of tissue CBDCA distribution would be warranted and may identify novel dosing strategies that could improve the therapeutic index of CBDCA by minimizing toxicity.
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