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Signal-dependent translation of a regulatory protein, Bcl-3, in activated human platelets.
- A. Weyrich, D. Dixon, +4 authors G. Zimmerman
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 12 May 1998
It is demonstrated that platelets synthesize and secrete numerous proteins besides Bcl-3 after they adhere to fibrinogen, which mediates adhesion and outside-in signaling of these cells by engagement of alphaIIb/beta3 integrin. Expand
Effects of NO modulation on cardiac arrhythmias in the rat isolated heart.
Investigation of modulation of NO levels by a blocker of its synthesis, by supplementation of its precursor, and by administration of an NO donor can influence reperfusion arrhythmias in the isolated rat heart found that NG-Nitro-L-arginine methyl ester increased the incidence of reperfusions-induced ventricular fibrillation. Expand
Integrin-dependent Control of Translation: Engagement of Integrin αIIbβ3 Regulates Synthesis of Proteins in Activated Human Platelets
- R. Pabla, A. Weyrich, +4 authors G. Zimmerman
- Biology, Medicine
- The Journal of cell biology
- 11 January 1999
Outside-in signals delivered by integrin αIIbβ3 are required for translation of Bcl-3 in thrombin-stimulated aggregated platelets and are sufficient to induce translation of this marker protein in the absence of throm bin. Expand
Endogenous protection against reperfusion-induced ventricular fibrillation: role of neuronal versus non-neuronal sources of nitric oxide and species dependence in the rat versus rabbit isolated heart.
A role for basally released NO as an endogenous antifibrillatory cardioprotectant in rat and rabbit isolated heart is indicated and species dependence is indicated, indicating that the tissue source (neuronal in rat but not in rabbit heart) is species-dependent. Expand
Effect of endogenous nitric oxide on cardiac systolic and diastolic function during ischemia and reperfusion in the rat isolated perfused heart.
Exogenous NO may delay the onset and reduce the magnitude of ischemic contracture but despite this, appears not to facilitate early recovery from systolic and diastolic stunning as a result of any direct action in the myocardium. Expand
An endogenous protectant effect of cardiac cyclic GMP against reperfusion‐induced ventricular fibrillation in the rat heart
- R. Pabla, P. Bland-Ward, P. Moore, M. J. Curtis
- British journal of pharmacology
- 1 December 1995
Cyclic GMP appears to be an endogenous intracellular cardioprotectant, and its actions may account for the low susceptibility to VF normally encountered in hearts reperfused after sustained ischaemia. Expand
Undiagnosed sleep apnoea syndrome in patients with acute myocardial infarction: potential importance of the STOP-BANG screening tool for clinical practice.
In this study of patients presenting with ACS to UK hospitals, 74% of those with confirmedMI had a STOP-BANG score suggestive of preexisting SAHS, consistent with those from two recent PSG-based studies of patients with acute MI. Expand
Nitric oxide attenuates neutrophil-mediated myocardial contractile dysfunction after ischemia and reperfusion.
PMN-mediated myocardial contractile dysfunction is attenuated by NO and exacerbated by blockade of NO synthesis, as evidence by a 93% reduction in LVDP at 45 minutes of reperfusion and a 91% reduce in PRP. Expand
Intracoronary nitric oxide improves postischemic coronary blood flow and myocardial contractile function.
- R. Pabla, A. Buda, D. Flynn, D. Salzberg, D. Lefer
- The American journal of physiology
- 1 September 1995
It is demonstrated that intracoronary administration of NO significantly augments postischemic coronary blood flow and contractile function following ischemia and reperfusion and reduces coronary vascular injury, attenuates myocardial necrosis, and reduces neutrophil infiltration. Expand
Cobalt uptake enables identification of capsaicin- and bradykinin-sensitive subpopulations of rat dorsal root ganglion cellsin vitro
- I. Nagy, R. Pabla, C. Matesz, A. Dray, C. Woolf, L. Urbán
- Medicine, Chemistry
- 1 September 1993
A novel modification of the stimulated cobalt uptake technique has been used to identify rat dorsal root ganglion cells expressing capsaicin and bradykinin receptors, and the distribution of cell diameters revealed that while Capsaicin-sensitive cells were exclusively small-sized, brady Kinin- sensitive cells were predominantly small and medium sized. Expand