• Publications
  • Influence
Circadian variation in serum free and non‐SHBG‐bound testosterone in normal men: measurements, and simulation using a mass action model
OBJECTIVE We measured the changes in testosterone fractions in serum of normal men over a 24‐hour period, and determined whether they could be simulated on the basis of current understanding of theExpand
  • 78
  • 3
Characteristics of the ACTH response to repeated pulses of corticotrophin-releasing factor and arginine vasopressin in vitro.
A multi-column perifusion system was used to investigate the dynamics of the dose-response relationships of ACTH release by ovine pituitary cells when stimulated by both corticotrophin-releasingExpand
  • 35
  • 3
Varying the patterns and concentrations of gonadotrophin-releasing hormone stimulation does not alter the ratio of LH and FSH released from perifused sheep pituitary cells.
Our aim was to determine whether release of LH and FSH can be controlled differentially by the characteristics of applied signals of stimulatory gonadotrophin-releasing hormone (GnRH) alone, free ofExpand
  • 17
  • 3
Mathematical Modelling and Computers in Endocrinology
  • 123
  • 2
Coupling of inositol phospholipid hydrolysis to peptide hormone receptors expressed from adrenal and pituitary mRNA in Xenopus laevis oocytes.
  • R. P. McIntosh, K. Catt
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1 December 1987
The expression of several neurotransmitter and drug receptors from injected exogenous mRNA in Xenopus laevis oocytes has been demonstrated by electrophysiological measurements of ion channelExpand
  • 32
  • 1
  • PDF
Influence of the characteristics of pulses of gonadotrophin releasing hormone on the dynamics of luteinizing hormone release from perifused sheep pituitary cells.
The effects were studied of varying the frequency, width and amplitude of pulses of gonadotrophin releasing hormone (GnRH) on the release of LH from anterior pituitary cells. Dispersed sheep cellsExpand
  • 53
  • 1
Differential modulation of Ca2+-activated K+ channels in ovine pituitary gonadotrophs by GnRH, Ca2+ and cyclic AMP
Patch-clamp techniques were employed to examine the effects of cAMP in relation to gonadotrophin-releasing hormone (GnRH) action on Ca2+-activated K+ channels in pituitary gonadotrophs derived fromExpand
  • 31
  • 1
Mathematical analysis of perifusion data: models predicting elution concentration.
System models are constructed and analyzed for combined convective flow and for dispersion in distorting concentrations of a chemical signal as it passes through a packed column. We derive generalExpand
  • 8
  • 1
Metabolism of the biologically active inositol phosphates Ins(1,4,5)P3 and Ins(1,3,4,5)P4 by ovarian follicles of Xenopus laevis.
The metabolism of biologically active inositol phosphates in developed ovarian follicles from Xenopus laevis was investigated. Techniques used were microinjection of tracer into the intact oocyteExpand
  • 15
  • PDF
Angiotensin II stimulates an endogenous response in Xenopus laevis ovarian follicles.
While responses to angiotensin II have previously been induced in Xenopus laevis oocytes after injection of messenger RNA extracted from mammalian tissue, no endogenous responses of ovarian tissue toExpand
  • 22