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Multicomponent reactions: advanced tools for sustainable organic synthesis
Sustainable or green chemistry has established firm ground providing essential design criteria for the development of efficient chemical syntheses of complex, high added value molecules. On the other… Expand
YidC Is Involved in the Biogenesis of the Secreted Autotransporter Hemoglobin Protease*
- W. Jong, C. T. ten Hagen-Jongman, E. Ruijter, R. Orru, P. Genevaux, J. Luirink
- Biology, Medicine
- The Journal of Biological Chemistry
- 19 October 2010
Autotransporters (ATs) constitute an important family of virulence factors secreted by Gram-negative bacteria. Following their translocation across the inner membrane (IM), ATs temporarily reside in… Expand
Stereoselectivities of microbial epoxide hydrolases.
Epoxide hydrolases from bacterial and fungal sources are highly versatile biocatalysts for the asymmetric hydrolysis of epoxides on a preparative scale. Besides kinetic resolution, which yields the… Expand
Hydroxynitrile Lyase from Arabidopsis thaliana: Identification of Reaction Parameters for Enantiopure Cyanohydrin Synthesis by Pure and Immobilized Catalyst
- Daniel Okrob, Monica Paravidino, R. Orru, W. Wiechert, U. Hanefeld, M. Pohl
- 1 September 2011
The (R)-selective hydroxynitrile lyase from Arabidopsis thaliana (AtHNL) is a promising biocatalyst for the synthesis of a broad range of chiral cyanohydrins. However, the enantiomeric excess of the… Expand
Multicomponent Reaction Design in the Quest for Molecular Complexity and Diversity
Efficient library synthesis of imidazoles using a multicomponent reaction and microwave irradiation
- E. Gelens, F. J. J. D. Kanter, +6 authors R. Orru
- Chemistry, Medicine
- Molecular Diversity
- 1 February 2006
Optimization of Radziszewski's four-component reaction employing a microwave-assisted protocol, led to a small library of 48 imidazoles with a success rate of 65% (conversion > 45%). All three… Expand
Multicomponent reaction design in the quest for molecular complexity and diversity.
Multicomponent reactions have become increasingly popular as tools for the rapid generation of small-molecule libraries. However, to ensure sufficient molecular diversity and complexity, there is a… Expand
A highly efficient synthesis of telaprevir by strategic use of biocatalysis and multicomponent reactions.
A very short and efficient synthesis of the important drug candidate telaprevir, featuring a biocatalytic desymmetrization and two multicomponent reactions as the key steps, is presented. The… Expand
The efficient one-pot reaction of up to eight components by the union of multicomponent reactions.
The development of synthetic methods has advanced enormously in the past decades. At present, chemists can design and prepare almost any type of molecule. The typical approach for the synthesis of… Expand
A resource-efficient and highly flexible procedure for a three-component synthesis of 2-imidazolines.
- N. Elders, R. F. Schmitz, F. D. de Kanter, E. Ruijter, M. Groen, R. Orru
- Chemistry, Medicine
- The Journal of organic chemistry
- 12 July 2007
A multicomponent reaction between alpha-acidic isonitriles, primary amines, and carbonyl compounds was studied using 14 different solvents. Depending on the isocyanide that was used, optimal yields… Expand