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FORTIMICINS A AND B, NEW AMINOGLYCOSIDE ANTIBIOTICS
The aminoglycoside antibiotics fortimicins A and B produced by a naturally occurring strain Micromonospora sp. MK-70 were isolated from its fermentation beer. Fortimicins A and B were isolated as…
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K-26, a novel inhibitor of angiotensin I converting enzyme produced by an actinomycete K-26.
A novel inhibitor of angiotensin I converting enzyme (ACE), designated K-26, was isolated from the broth filtrate of an actiomycete K-26. K-26 is a water soluble, acidic peptide composed of an equal…
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Fortimicins A and B, new aminoglycoside antibiotics. I. Producing organism, fermentation and biological properties of fortimicins.
TLDR
A culture of Micromonospora species MK-70 was found to produce two new antibiotics, fortimicins A and B, which exhibited potent, unique, broad-spectrum antibacterial activity against Gram-positive and negative bacteria both in vitro and in vivo.
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Search for Microorganisms Producing Cephalosporin Acylase and Enzymatic Synthesis of Cephalosporins
TLDR
Ktuyvera citrophila KY 7844 was one of the most promising organisms for enzymatic synthesis of cephalosporins and had the ability to catalyze N-acylation of 7-aminocephem compound not only with α- amino acid ester, but also with such acid esters as 1-(1 H)-tetrazolylacetate methylester which has no α-Amino group.
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Enzymatic synthesis of cphalosporins. III. Purification and properties of penicillin acylase from Kluyvera citrophila.
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Selection of Pseudomonas melanogenum KY 3987 as a New Ampicillin-producing Bacteria
TLDR
Pseudomonas melanogenum KY 3987 was selected as a new strain possessing an APc-specific penicillin acylase, which could synthesize APc in good yields from 6–APA and phenylglycine ester and form 6– APA only from APc, not from other common penicillins.
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Fortimicin A production by Micromonospora olivoasterospora in a chemically defined medium.
TLDR
The most important finding was that vitamin B12, cobalt and nickel showed marked stimulatory effects on fortimicin A production.
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A new antibiotic victomycin (XK 49-1-B-2). I. Taxonomy and production of the producing organism.
A new antibiotic designated as victomycin which belongs to the phleomycin-bleomycin group antibiotics was isolated from a sporangia-forming actinomycete. From taxonomic studies, the producing strain…
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Isolation of Penicillinase-deficient Mutants of Kluyera citrophila KY 3641
Penicillinase-deficient mutants were isolated from Kluyvera citrophila KY 3641 capable of carrying out enzymatic synthesis of 6-aminopenicillanic acid (6-APA) or d(–)-α-amino-benzylpenicillin (APc).…
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Enzymatic Synthesis of D(-)-α-Aminobenzylpenicillin
In order to search for microorganisms able to synthesize D(−)-α~aminobenzylpenicillin (ampicillin) from 6-aminopenicillanic acid (6-APA), experiments were undertaken to screen out organisms…
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