• Publications
  • Influence
Avermectins, New Family of Potent Anthelmintic Agents: Producing Organism and Fermentation
The avermectins are a complex of chemically related agents which exhibit extraordinarily potent anthelmintic activity. They are produced by a novel species of actinomycete, NRRL 8165, which we have
A new antibiotic,, asukamycin, produced by Streptomyces.
The empirical formula of antibiotic asukamycin has been proposed as C29H22N2O9 (M.W. 542) and an acute toxicity of the antibiotic in mice is LD50 48.5 mg/kg by intraperitoneal injection and it has no effect on mice when it was administered by 450mg/kg per os.
Phosalacine, a new herbicidal antibiotic containing phosphinothricin. Fermentation, isolation, biological activity and mechanism of action.
It is suggested that phosalacine was decomposed to provide phosphinothricin after its incorporation into microbial or plant cells, and exhibited the antimicrobial and herbicidal activities by inhibiting glutamine synthetase with phosphinOTHricin although phosalACine itself hardly inhibited the enzyme.
Production of deoxyfrenolicin and a new antibiotic, frenolicin B by Streptomyces roseofulvus strain AM-3867.
Two antibiotics of frenolicin group were isolated from the fermentation broth of Streptomyces roseofulvus strain No.
Studies on bacterial cell wall inhibitors. VII. Azureomycins A and B, new antibiotics produced by Pseudonocardia azurea nov. sp. Taxonomy of the producing organism, isolation, characterization and
Two new basic water-soluble antibiotics, azureomycins A and B, were isolated from the culture broth of an actinomycete, strain AM-3696, designated as Pseudonocardia azurea nov. sp. The antibiotics
Nanaomycins, new antibiotics produced by a strain of Streptomyces. I. Taxonomy, isolation, characterization and biological properties.
The physical and chemical properties suggest that nanaomycins A and B are quinone-related compounds having the molecular formulae, C16H14O6 and C16 H16O7, respectively.
Clostomicins, new antibiotics produced by Micromonospora echinospora subsp. armeniaca subsp. nov. I. Production, isolation, and physico-chemical and biological properties.
A soil isolate named as KMR-593 was found to produce at least five related antibiotics, clostomicins, active against Gram-positive bacteria including anaerobes, and one of these components was identified with lipiarmycin and others were found to be new antibiotics.
Studies on bacterial cell wall inhibitors. II. Inhibition of peptidoglycan synthesis in vivo and in vitro by amphomycin.
The site of action of amphomycin is the formation of MurNAc-(pentapeptide)-P-P-lipid fromMurNAc-pentapePTide and undecaprenol (lipid) phosphate.