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Brown adipose tissue: physiological function and evolutionary significance
In modern eutherian (placental) mammals, brown adipose tissue (BAT) evolved as a specialized thermogenic organ that is responsible for adaptive non-shivering thermogenesis (NST). For NST, energyExpand
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Uncoupling Protein 1 Decreases Superoxide Production in Brown Adipose Tissue Mitochondria*
In thermogenic brown adipose tissue, uncoupling protein 1 (UCP1) catalyzes the dissipation of mitochondrial proton motive force as heat. In a cellular environment of high oxidative capacity such asExpand
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Hibernation in Free-Ranging African Woodland Dormice, Graphiurus murinus
Although daily torpor is common in African animals, hibernation seems to be uncommon. In this study we investigated the use of hibernation in free-ranging African woodland dormice, GraphiurusExpand
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Torpor patterns, arousal rates, and temporal organization of torpor entry in wildtype and UCP1-ablated mice
In eutherian mammals, uncoupling protein 1 (UCP1) mediated non-shivering thermogenesis from brown adipose tissue (BAT) provides a mechanism through which arousal from torpor and hibernation isExpand
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Seasonal changes in thermogenesis of a free-ranging afrotherian small mammal, the Western rock elephant shrew (Elephantulus rupestris)
We report on the seasonal metabolic adjustments of a small-sized member of the phylogenetically ancient Afrotheria, the Western rock elephant shrew (Elephantulus rupestris). We recorded bodyExpand
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Antioxidant properties of UCP1 are evolutionarily conserved in mammals and buffer mitochondrial reactive oxygen species.
Mitochondrial uncoupling reduces reactive oxygen species (ROS) production and appears to be important for cellular signaling/protection, making it a focus for the treatment of metabolic andExpand
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Low-level mitochondrial heteroplasmy modulates DNA replication, glucose metabolism and lifespan in mice
Mutations in mitochondrial DNA (mtDNA) lead to heteroplasmy, i.e., the intracellular coexistence of wild-type and mutant mtDNA strands, which impact a wide spectrum of diseases but also physiologicalExpand
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Editorial: The Evolution of Endothermy–From Patterns to Mechanisms
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Mitochondrial Proton Leak Compensates for Reduced Oxidative Power during Frequent Hypothermic Events in a Protoendothermic Mammal, Echinops telfairi
The lesser hedgehog tenrec (Echinops telfairi) displays reptile-like thermoregulatory behavior with markedly high variability in body temperature and metabolic rate. To understand how energyExpand
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