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Mitochondrial generation of free radicals and hypoxic signaling
Oxygen sensing and molecular adaptation to hypoxia.
Redox chemistry appears to play a critical role both in the trans-activation of oxygen-responsive genes in unicellular organisms as well as in the activation of HIF-1, which is required for the hypoxic induction of physiologically important genes.
Crosstalk between nuclear and mitochondrial genomes.
Molecular mechanisms that underlie the communication between the nuclear and mitochondrial genomes in eukaryotic cells and an understanding of OXPHOS diseases and aging are focused on.
Mitochondrial cytochrome oxidase produces nitric oxide under hypoxic conditions: implications for oxygen sensing and hypoxic signaling in eukaryotes.
Oxygen sensing and the transcriptional regulation of oxygen-responsive genes in yeast.
The transcriptional regulation of oxygen-responsive genes is provided, the functional roles that heme and hemoproteins may play in this regulation are addressed, and possible mechanisms of oxygen sensing in this simple eukaryotic organism are discussed.
Effects of Oxygen Concentration on the Expression of Cytochrome c and Cytochrome c Oxidase Genes in Yeast*
- P. V. Burke, D. Raitt, L. Allen, E. Kellogg, R. O. Poyton
- BiologyThe Journal of Biological Chemistry
- 6 June 1997
It is found that aerobic genes are induced faster than hypoxic genes and that transcripts from both types of gene are turned over quickly and have important implications for cytochrome coxidase function and biogenesis and for models of oxygen sensing in yeast.
Oxygen sensing in yeast: evidence for the involvement of the respiratory chain in regulating the transcription of a subset of hypoxic genes.
- K. Kwast, P. V. Burke, B. Staahl, R. O. Poyton
- BiologyProceedings of the National Academy of Sciences…
- 11 May 1999
It is found that carbon monoxide completely blocks the anoxia-induced expression of two hypoxic genes, OLE1 and CYC7, partially blocks the induction of a third gene, COX5b, and has no effect on the expression of other hypoxic or aerobic genes.
A Mechanism of Oxygen Sensing in Yeast
It is found that Hap1 activity is controlled in vivo by heme and not by its precursors and that heme activates HAP1 even in anoxic cells, and multiple heme synthetic steps can sense oxygen concentration.
Therapeutic photobiomodulation: nitric oxide and a novel function of mitochondrial cytochrome c oxidase.
It is proposed that cytochrome c oxidase functions in photobiomodulation by producing nitric oxide, a signaling molecule which can then function in both intra- and extracellular signaling pathways, and that the effectiveness of photobiOModulation is under the control of tissue oxygen and nitrite levels.
Structure/function of oxygen-regulated isoforms in cytochrome c oxidase.
The level of cytochrome c oxidase activity that is produced at different oxygen tensions in yeast is determined in part by the number of holoenzyme molecules that are assembled and in partBy the oxygen-regulated isoforms of subunit V.