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Combination of Hypomorphic Mutations of the Drosophila Homologues of Aryl Hydrocarbon Receptor and Nucleosome Assembly Protein Family Genes Disrupts Morphogenesis, Memory and Detoxification
Aryl hydrocarbon receptor is essential for biological responses to endogenous and exogenous toxins in mammals. Its Drosophila homolog spineless plays an important role in fly morphogenesis. We haveExpand
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Xenobiotic-induced activation of human aryl hydrocarbon receptor target genes in Drosophila is mediated by the epigenetic chromatin modifiers
Aryl hydrocarbon receptor (AHR) is the key transcription factor that controls animal development and various adaptive processes. The AHR’s target genes are involved in biodegradation of endogenousExpand
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NAP Family CG5017 Chaperone Pleiotropically Regulates Human AHR Target Genes Expression in Drosophila Testis
To study the regulatory mechanism of the Aryl hydrocarbon receptor (AHR), target genes of transcription are necessary for understanding the normal developmental and pathological processes. Here, weExpand
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[Effect of mutations in lawc/Trf2 gene on development of chromocenter and chromosome disjunction in Drosophila melanogaster].
In Drosophila, one of the genes of the lawc/Trf2 (leg-arista-wing complex/TBP-related factor 2) complex encodes an alternative basic transcription factor homologous to the TRF2 protein in vertebratesExpand
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[Influence of hairpin RNA, specific to the gene lawc, on expression of overlapping genes of the lawc/Trf2 complex in D. melanogaster].
We used a genetic system of the gene complex leg-arista-wing complex/TBP related factor 2 (lawc/Trf2) as a suitable model for in vivo study of operational characteristics of divergent overlappingExpand
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[Aryl-hydrocarbon receptor as a potential target for anticancer therapy].
Aryl-hydrocarbon receptor (Aryl Hydrocarbon Receptor, AHR) is a ligand-dependent transcription factor, whose functions are related to xenobiotic detoxification, response to inflammation, andExpand
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Screening of genomic regions affecting lawc/Trf2 gene expression during Drosophila melanogaster development
Abstractleg-arista-wing complex (lawc) mutations affect the expression of Drosophila proteins homologous to a human basic transcription factor, TBP (TATA-box binding protein) Related Factor 2 (TRF2),Expand
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Overlapping genes and antisense transcription in eukaryotes
Numerous studies showed that overlapping genes are fairly common elements of genome organization, not only in viruses and prokaryotes but also in eukaryotes. At the same time, the regulatoryExpand
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Effect of mutations in lawc/Trf2 gene on chromocenter formation and chromosome segregation in Drosophila melanogaster
In Drosophila, one of the genes of the lawc/Trf2 (leg-arista-wing complex/TBP-related factor 2) complex encodes an alternative basic transcription factor homologous to the TRF2 protein in vertebratesExpand
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The Effect of TBP-Related Factor 2 on Chromocenter Formation and Chromosome Segregation in Drosophila Melanogaster
Chromosome nondisjunction in meiosis causes the gene disbalance and a number of anomalies in development and fertility. Otherwise, genetically programmed sex-ratio meiotic drive occurs in a number ofExpand
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