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By Carrot or by Stick: Cognitive Reinforcement Learning in Parkinsonism
To what extent do we learn from the positive versus negative outcomes of our decisions? The neuromodulator dopamine plays a key role in these reinforcement learning processes. Patients withExpand
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A mechanistic account of striatal dopamine function in human cognition: psychopharmacological studies with cabergoline and haloperidol.
The authors test a neurocomputational model of dopamine function in cognition by administering to healthy participants low doses of D2 agents cabergoline and haloperidol. The model suggests that DAExpand
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Conjunctive representations in learning and memory: principles of cortical and hippocampal function.
The authors present a theoretical framework for understanding the roles of the hippocampus and neocortex in learning and memory. This framework incorporates a theme found in many theories ofExpand
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Biologically Based Computational Models of High-Level Cognition
Computer models based on the detailed biology of the brain can help us understand the myriad complexities of human cognition and intelligence. Here, we review models of the higher level aspects ofExpand
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Towards an executive without a homunculus: computational models of the prefrontal cortex/basal ganglia system
The prefrontal cortex (PFC) has long been thought to serve as an ‘executive’ that controls the selection of actions and cognitive functions more generally. However, the mechanistic basis of thisExpand
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A computational approach to prefrontal cortex, cognitive control and schizophrenia: recent developments and current challenges.
In this chapter we consider the mechanisms involved in cognitive control-from both a computational and a neurobiological perspective- and how these might be impaired in schizophrenia. By 'control',Expand
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Hippocampal formation supports conditioning to memory of a context.
It has been proposed that contextual fear conditioning depends on 2 processes: (a) construction of a conjunctive representation of the features that make up the context and (b) association of theExpand
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When logic fails: Implicit transitive inference in humans
Transitive inference (TI) in animals (e.g., choosing A over C on the basis of knowing that A is better than B and B is better than C) has been interpreted by some as reflecting a declarative logicalExpand
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Contextual fear conditioning, conjunctive representations, pattern completion, and the hippocampus.
Impaired contextual fear conditioning produced by damage to the hippocampus has been attributed to the loss of a conjunctive representation of the features of the context. There is, however, noExpand
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The What and How of prefrontal cortical organization
  • R. O'Reilly
  • Psychology, Medicine
  • Trends in Neurosciences
  • 1 August 2010
How is the prefrontal cortex (PFC) organized such that it is capable of making people more flexible and in control of their behavior? Is there any systematic organization across the many diverseExpand
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