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Genetics of osteoporosis
Estrogen receptor gene polymorphisms and the genetics of osteoporosis: a HuGE review.
A further promising application of these polymorphisms comes from their pharmacogenomic implications, with the possibility of providing better guidance for therapeutic regimens, such as estrogen replacement therapy and selective ER modulators.
Circulating sclerostin levels and bone turnover in type 1 and type 2 diabetes.
Findings suggest that sclerostin is increased in DM2, a condition of low bone turnover and decreased osteoblast activity in both type 1 and 2 diabetes mellitus, and the transcriptional suppression of sclerOSTin production by PTH might be impaired in both DM1 and DM2.
Prevalence of Paget's Disease of Bone in Italy
No secular trend for a decreasing prevalence emerged in populations of British descent from radiological, scintigraphic, and biochemical surveys in two Italian towns.
Influence of insulin-like growth factor-1 and leptin on bone mass in healthy postmenopausal women.
It is concluded that serum IGF-1 and serum leptin have no direct effect on bone mass and bone turnover independent of body weight.
SQSTM1 gene analysis and gene‐environment interaction in Paget's disease of bone
It is suggested that animal‐related factors may be important in the etiology of PDB and may interact with SQSTM1 mutations in influencing disease severity.
Aromatase activity and bone homeostasis in men.
Confirmatory evidence comes from recent interventional studies in adult men using aromatase inhibition, which confirmed that estrogens are critically important to the male skeleton by helping to control rates of bone remodeling.
Erythropoietin improves anemia exercise tolerance and renal function and reduces B-type natriuretic peptide and hospitalization in patients with heart failure and anemia.
In anemic CHF patients, correction of anemia with EPO and oral iron leads to improvement in New York Heart Association status, measured exercise endurance, oxygen use during exercise, renal function and plasma B-type natriuretic peptide levels and reduces the need for hospitalization.
Paget's Disease of Bone in Italy
PDB is confirmed to be the most common bone remodeling disorder in elderly people in Italy, excluding osteoporosis, and a consistent association between PDB and animal‐related factors and a significantly higher prevalence of the disease in rural than in urban districts were observed.
Effects of beta-erythropoietin treatment on left ventricular remodeling, systolic function, and B-type natriuretic peptide levels in patients with the cardiorenal anemia syndrome.
In anemic patients with CHF, correction of anemia with EPO and oral iron over 1 year lead to an improvement in LV systolic function, LV remodeling, BNP levels, and PAP compared with a control group in which only oral iron was used.