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The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease
Alzheimer’s disease (AD) is characterized by deposition of amyloid-β (Aβ) plaques and neurofibrillary tangles in the brain, accompanied by synaptic dysfunction and neurodegeneration. Antibody-basedExpand
Formation of Neurofibrillary Tangles in P301L Tau Transgenic Mice Induced by Aβ42 Fibrils
β-Amyloid plaques and neurofibrillary tangles (NFTs) are the defining neuropathological hallmarks of Alzheimer's disease, but their pathophysiological relation is unclear. Injection of β-amyloid Aβ42Expand
Acute cortisone administration impairs retrieval of long-term declarative memory in humans
1. Hazelrigg, T. Cell 95, 451–460 (1998). 2. Tiedge, H., Bloom, F. E. & Richter, D. Science 283, 186–187 (1999). 3. Huang, E. P. Curr. Biol. 9, R168–R170 (1999). 4. Gao, F. B. Bioessays 20, 7–78Expand
Tau Filament Formation in Transgenic Mice Expressing P301L Tau*
Mutations in the microtubule-associated protein tau, including P301L, are genetically coupled to hereditary frontotemporal dementia with parkinsonism linked to chromosome 17. To determine whetherExpand
The Human DIMINUTO/DWARF1 Homolog Seladin-1 Confers Resistance to Alzheimer's Disease-Associated Neurodegeneration and Oxidative Stress
In Alzheimer's disease (AD) brains, selected populations of neurons degenerate heavily, whereas others are frequently spared from degeneration. To address the cellular basis for this selectiveExpand
Low-dose cortisol for symptoms of posttraumatic stress disorder.
OBJECTIVE Because elevated cortisol levels inhibit memory retrieval in healthy human subjects, the present study investigated whether cortisol administration might also reduce excessive retrieval ofExpand
Age-Dependent Neurodegeneration and Alzheimer-Amyloid Plaque Formation in Transgenic Drosophila
β-Amyloid peptides that are cleaved from the amyloid precursor protein (APP) play a critical role in Alzheimer's disease (AD) pathophysiology. Here, we show that in Drosophila, the targetedExpand
Better Memory and Neural Efficiency in Young Apolipoprotein E ε4 Carriers
The apolipoprotein E (APOE) epsilon4 allele is the major genetic risk factor for Alzheimer's disease, but an APOE effect on memory performance and memory-related neurophysiology in young, healthyExpand
Glucocorticoid‐induced impairment of declarative memory retrieval is associated with reduced blood flow in the medial temporal lobe
Previous work indicates that stress levels of circulating glucocorticoids can impair retrieval of declarative memory in human subjects. Several studies have reported that declarative memory retrievalExpand
The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor
The physiological functions of the beta-amyloid precursor protein (APP) may include nuclear signaling. To characterize the role of the APP adaptor proteins Fe65, Jip1b, X11α (MINT1) and theExpand
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