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Identification of agrin, a synaptic organizing protein from Torpedo electric organ
Extracts of the electric organ of Torpedo californica contain a proteinaceous factor that causes the formation of patches on cultured myotubes at which acetylcholine receptors (AChR),Expand
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Components of Torpedo electric organ and muscle that cause aggregation of acetylcholine receptors on cultured muscle cells
The synaptic portion of a muscle fiber's basal lamina sheath has molecules tightly bound to it that cause aggregation of acetylcholine receptors (AChRs) on regenerating myofibers. Since basal laminaExpand
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Acetylcholine receptor-aggregating factor is similar to molecules concentrated at neuromuscular junctions
The basal lamina in the synaptic cleft of the vertebrate skeletal neuromuscular junction contains molecules that direct the formation of synaptic specializations in regenerating axons and muscleExpand
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Aggregates of acetylcholinesterase induced by acetylcholine receptor-aggregating factor
Basal lamina-rich extracts of Torpedo californica electric organ contain a factor that causes acetylcholine receptors (AChRs) on cultured myotubes to aggregate into patches1–3. Our previous studiesExpand
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Gaucher disease. Current issues in diagnosis and treatment. NIH Technology Assessment Panel on Gaucher Disease.
OBJECTIVE To provide physicians with a responsible assessment of the diagnosis and treatment of Gaucher disease. PARTICIPANTS A nonfederal, nonadvocate, 14-member panel representing the fields ofExpand
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Molecular components of the synaptic basal lamina that direct differentiation of regenerating neuromuscular junctions.
Results of experiments outlined here provide evidence that components of the myofiber basal lamina sheath direct the formation of active zones in regenerating motor nerve terminals and theExpand
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Role of cardiac atria in the human renal response to changing plasma volume.
We examined the role of cardiac atria in the renal response to sequential volume expansion and contraction, during and directly following water immersion. In immersed healthy volunteers (group 1, n =Expand
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Agrin-induced reorganization of extracellular matrix components on cultured myotubes: relationship to AChR aggregation
Agrin, an extracellular matrix-associated protein extracted from synapse-rich tissues, induces the accumulation of acetylcholine receptors (AChRs) and other synaptic components into discrete patchesExpand
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Internalization of alpha-bungarotoxin on neurons induced by a neurotoxin that blocks neuronal acetylcholine sensitivity
A protein neurotoxin (Bgt 3.1) present as a minor component in the venom of Bungarus multicinctus has been shown previously to block acetylcholine (ACh) sensitivity on chick ciliary ganglion (CG)Expand
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Agrin induces alpha-actinin, filamin, and vinculin to co-localize with AChR clusters on cultured chick myotubes.
Agrin induces discrete high-density patches of acetylcholine receptors (AChRs) and other synaptic components on cultured myotubes in a manner that resembles synaptic differentiation. Furthermore,Expand
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