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A Draft Sequence of the Neandertal Genome
Kissing Cousins Neandertals, our closest relatives, ranged across Europe and Southwest Asia before their extinction approximately 30,000 years ago. Green et al. (p. 710) report a draft sequence ofExpand
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Likelihood models for detecting positively selected amino acid sites and applications to the HIV-1 envelope gene.
Several codon-based models for the evolution of protein-coding DNA sequences are developed that account for varying selection intensity among amino acid sites. The "neutral model" assumes twoExpand
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A metagenome-wide association study of gut microbiota in type 2 diabetes
Assessment and characterization of gut microbiota has become a major research area in human disease, including type 2 diabetes, the most prevalent endocrine disease worldwide. To carry out analysisExpand
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Population genomics of Bronze Age Eurasia
The Bronze Age of Eurasia (around 3000–1000 BC) was a period of major cultural changes. However, there is debate about whether these changes resulted from the circulation of ideas or from humanExpand
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A recent bottleneck of Y chromosome diversity coincides with a global change in culture.
It is commonly thought that human genetic diversity in non-African populations was shaped primarily by an out-of-Africa dispersal 50-100 thousand yr ago (kya). Here, we present a study of 456Expand
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Statistical inferences in phylogeography
In conventional phylogeographic studies, historical demographic processes are elucidated from the geographical distribution of individuals represented on an inferred gene tree. However, theExpand
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On Detecting Incomplete Soft or Hard Selective Sweeps Using Haplotype Structure
We present a new haplotype-based statistic (nSL) for detecting both soft and hard sweeps in population genomic data from a single population. We compare our new method with classic single-populationExpand
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The Genetic Cost of Neanderthal Introgression
Approximately 2–4% of genetic material in human populations outside Africa is derived from Neanderthals who interbred with anatomically modern humans. Recent studies have shown that this NeanderthalExpand
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Convergent evolution of the genomes of marine mammals
Marine mammals from different mammalian orders share several phenotypic traits adapted to the aquatic environment and therefore represent a classic example of convergent evolution. To investigateExpand
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Early Divergent Strains of Yersinia pestis in Eurasia 5,000 Years Ago
Summary The bacteria Yersinia pestis is the etiological agent of plague and has caused human pandemics with millions of deaths in historic times. How and when it originated remains contentious. Here,Expand
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