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- Publications
- Influence
A Draft Sequence of the Neandertal Genome
- R. E. Green, J. Krause, +53 authors S. Pääbo
- Biology, Medicine
- Science
- 7 May 2010
Kissing Cousins Neandertals, our closest relatives, ranged across Europe and Southwest Asia before their extinction approximately 30,000 years ago. Green et al. (p. 710) report a draft sequence of… Expand
Likelihood models for detecting positively selected amino acid sites and applications to the HIV-1 envelope gene.
- R. Nielsen, Z. Yang
- Biology, Medicine
- Genetics
- 1 March 1998
Several codon-based models for the evolution of protein-coding DNA sequences are developed that account for varying selection intensity among amino acid sites. The "neutral model" assumes two… Expand
A metagenome-wide association study of gut microbiota in type 2 diabetes
Assessment and characterization of gut microbiota has become a major research area in human disease, including type 2 diabetes, the most prevalent endocrine disease worldwide. To carry out analysis… Expand
Population genomics of Bronze Age Eurasia
- M. Allentoft, M. Sikora, +63 authors E. Willerslev
- Biology, Medicine
- Nature
- 11 June 2015
The Bronze Age of Eurasia (around 3000–1000 BC) was a period of major cultural changes. However, there is debate about whether these changes resulted from the circulation of ideas or from human… Expand
A recent bottleneck of Y chromosome diversity coincides with a global change in culture.
- Monika Karmin, L. Saag, +97 authors T. Kivisild
- Biology, Medicine
- Genome research
- 1 April 2015
It is commonly thought that human genetic diversity in non-African populations was shaped primarily by an out-of-Africa dispersal 50-100 thousand yr ago (kya). Here, we present a study of 456… Expand
Statistical inferences in phylogeography
- R. Nielsen, M. Beaumont
- Biology, Medicine
- Molecular ecology
- 1 March 2009
In conventional phylogeographic studies, historical demographic processes are elucidated from the geographical distribution of individuals represented on an inferred gene tree. However, the… Expand
On Detecting Incomplete Soft or Hard Selective Sweeps Using Haplotype Structure
- A. Ferrer-Admetlla, M. Liang, T. Korneliussen, R. Nielsen
- Biology, Medicine
- Molecular biology and evolution
- 18 February 2014
We present a new haplotype-based statistic (nSL) for detecting both soft and hard sweeps in population genomic data from a single population. We compare our new method with classic single-population… Expand
The Genetic Cost of Neanderthal Introgression
- Kelley Harris, R. Nielsen
- Biology, Medicine
- Genetics
- 1 April 2016
Approximately 2–4% of genetic material in human populations outside Africa is derived from Neanderthals who interbred with anatomically modern humans. Recent studies have shown that this Neanderthal… Expand
Convergent evolution of the genomes of marine mammals
Marine mammals from different mammalian orders share several phenotypic traits adapted to the aquatic environment and therefore represent a classic example of convergent evolution. To investigate… Expand
Early Divergent Strains of Yersinia pestis in Eurasia 5,000 Years Ago
- S. Rasmussen, M. Allentoft, +28 authors E. Willerslev
- Biology, Medicine
- Cell
- 22 October 2015
Summary The bacteria Yersinia pestis is the etiological agent of plague and has caused human pandemics with millions of deaths in historic times. How and when it originated remains contentious. Here,… Expand