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The nature and determinants of neuropsychological functioning in late-life depression.
CONTEXT Cognitive impairment in late-life depression (LLD) is highly prevalent, disabling, poorly understood, and likely related to long-term outcome. OBJECTIVES To determine the characteristicsExpand
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Frequent amyloid deposition without significant cognitive impairment among the elderly.
OBJECTIVE To characterize the prevalence of amyloid deposition in a clinically unimpaired elderly population, as assessed by Pittsburgh Compound B (PiB) positron emission tomography (PET) imaging,Expand
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Patterns of Hand Preference in a Student Population
The handedness of 1599 college students was assessed using a modification of Annett's (1967) inventory. The addition of a strength of preference scale makes the "mixed" classification a betterExpand
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Regional cerebral blood flow during word and nonword reading
The purpose of this study was to examine changes in regional cerebral blood flow (rCBF) using positron emission tomography (PET) during overt word and nonword reading tasks to determine structuresExpand
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Self-reported sleep quality predicts poor cognitive performance in healthy older adults.
This study examined the relation between sleep quality and cognitive performance in older adults, controlling for common medical comorbidities. Participants were community volunteers who, while notExpand
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Decreased working memory and processing speed mediate cognitive impairment in geriatric depression.
BACKGROUND While neuropsychological dysfunction is common in geriatric depression, not all aspects of cognition are equally affected. It has been suggested that depressed patients are impaired onlyExpand
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Basal Cerebral Metabolism May Modulate the Cognitive Effects of Aβ in Mild Cognitive Impairment: An Example of Brain Reserve
Inverse correlations between amyloid-β (Aβ) load measured by Pittsburgh Compound-B (PiB) positron emission tomography (PET) and cerebral metabolism using [18F]fluoro-2-deoxy-d-glucose (FDG) inExpand
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Complementary Category Learning Systems Identified Using Event-Related Functional MRI
Event-related fMRI was used to dissociate the neural systems involved in category learning with and without awareness. Ten subjects performed a speeded response category learning task. Functional MRExpand
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Changes in cognitive functioning following treatment of late-life depression.
OBJECTIVE Knowledge of the relationship between various clinical characteristics and cognitive functioning is advancing, but little is known about the cognitive response to treatment for geriatricExpand
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A positron emission tomography (PET) study of autobiographical memory retrieval.
Memory for the experiences of one's life, autobiographical memory (AM), is one of the most human types of memory, yet comparatively little is known of its neurobiology. A positron emission tomographyExpand
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