• Publications
  • Influence
All three SOS‐inducible DNA polymerases (Pol II, Pol IV and Pol V) are involved in induced mutagenesis
Most organisms contain several members of a recently discovered class of DNA polymerases (umuC/dinB superfamily) potentially involved in replication of damaged DNA. In Escherichia coli, only Pol VExpand
  • 360
  • 15
  • PDF
Carcinogen-induced frameshift mutagenesis in repetitive sequences.
We have constructed plasmids pS3G-1 and pSG4 that contain single acetylaminofluorene adducts within contiguous runs of three (5'-CCCG1G2G3-3') and four (5'-CG1GGG4T-3') guanine residues,Expand
  • 98
SOS factors involved in translesion synthesis.
Mutations are permanent DNA sequence changes that can be induced when replication occurs on a damaged DNA template. In Escherichia coli, the process of translesion synthesis past a lesion thatExpand
  • 54
DNA sequence determinants of carcinogen-induced frameshift mutagenesis.
In order to examine the mechanisms of induced frameshift mutagenesis, we constructed double-stranded DNA plasmids which contain single N-2-acetylaminofluorene (AAF) adducts at specified positionsExpand
  • 36
Inactivation of DNA proofreading obviates the need for SOS induction in frameshift mutagenesis.
  • R. Fuchs, R. Napolitano
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 27 October 1998
Translesion synthesis at replication-blocking lesions requires the induction of proteins that are controlled by the SOS system in Escherichia coli. Of the proteins identified so far, UmuD', UmuC, andExpand
  • 25
  • PDF
New strategy for the construction of single-stranded plasmids with single mutagenic lesions.
Single-stranded DNA vectors containing single adducts offer a unique opportunity to study the biochemistry and genetics of trans lesion synthesis, a process during which a DNA polymerase synthesizesExpand
  • 27
DNA repair and sequence context affect 1O2-induced mutagenesis in bacteria
TLDR
In this work, the mutagenicity induced by (1)O(2) in a defined sequence of DNA was investigated after replication in Escherichia coli mutants deficient for nucleotide and base excision DNA repair pathways. Expand
  • 19
  • PDF
Mecanisme de la mutagenese frameshift induite
L'agent mutagene n-2-acetylaminofluorene forme un adduit sur la guanine qui constitue un bloc pour la replication de l'adn. Cette lesion va induire des mutations de type frameshift au sein deExpand