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All three SOS‐inducible DNA polymerases (Pol II, Pol IV and Pol V) are involved in induced mutagenesis
Most organisms contain several members of a recently discovered class of DNA polymerases (umuC/dinB superfamily) potentially involved in replication of damaged DNA. In Escherichia coli, only Pol VExpand
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Carcinogen-induced frameshift mutagenesis in repetitive sequences.
We have constructed plasmids pS3G-1 and pSG4 that contain single acetylaminofluorene adducts within contiguous runs of three (5'-CCCG1G2G3-3') and four (5'-CG1GGG4T-3') guanine residues,Expand
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SOS factors involved in translesion synthesis.
Mutations are permanent DNA sequence changes that can be induced when replication occurs on a damaged DNA template. In Escherichia coli, the process of translesion synthesis past a lesion thatExpand
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DNA sequence determinants of carcinogen-induced frameshift mutagenesis.
In order to examine the mechanisms of induced frameshift mutagenesis, we constructed double-stranded DNA plasmids which contain single N-2-acetylaminofluorene (AAF) adducts at specified positionsExpand
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Inactivation of DNA proofreading obviates the need for SOS induction in frameshift mutagenesis.
  • R. Fuchs, R. Napolitano
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 27 October 1998
Translesion synthesis at replication-blocking lesions requires the induction of proteins that are controlled by the SOS system in Escherichia coli. Of the proteins identified so far, UmuD', UmuC, andExpand
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New strategy for the construction of single-stranded plasmids with single mutagenic lesions.
Single-stranded DNA vectors containing single adducts offer a unique opportunity to study the biochemistry and genetics of trans lesion synthesis, a process during which a DNA polymerase synthesizesExpand
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DNA repair and sequence context affect 1O2-induced mutagenesis in bacteria
In this work, the mutagenicity induced by (1)O(2) in a defined sequence of DNA was investigated after replication in Escherichia coli mutants deficient for nucleotide and base excision DNA repair pathways. Expand
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Mecanisme de la mutagenese frameshift induite
L'agent mutagene n-2-acetylaminofluorene forme un adduit sur la guanine qui constitue un bloc pour la replication de l'adn. Cette lesion va induire des mutations de type frameshift au sein deExpand