R. Nakata

Publications99
h-index22
Citations1,414
Highly Influential Citations50
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Carvacrol, a component of thyme oil, activates PPARα and γ and suppresses COX-2 expression[S]
TLDR
It is shown that COX-2 promoter activity was suppressed by essential oils derived from thyme, clove, rose, eucalyptus, fennel, and bergamot in cell-based transfection assays using bovine arterial endothelial cells, suggesting that carvacrol regulates COx-2 expression through its agonistic effect on PPARγ.
Recent advances in the study on resveratrol.
TLDR
A review of the studies on resveratrol is provided, especially with respect to COX, PPAR, and eNOS activities, and its potential for promoting human health is discussed.
Farnesol, an isoprenoid, improves metabolic abnormalities in mice via both PPARα-dependent and -independent pathways.
TLDR
It is shown that farnesol, a naturally occurring ligand of PPARs, could ameliorate metabolic diseases and that the activation of FXR byfarnesol might contribute partially to the PPARα-independent hepatic triglyceride content-lowering effect.
Up-regulation of endothelial nitric oxide synthase (eNOS), silent mating type information regulation 2 homologue 1 (SIRT1) and autophagy-related genes by repeated treatments with resveratrol in human…
TLDR
Resveratrol treatment increased the expression of autophagy-regulated genes such as γ-aminobutyric acid A receptor-associated protein (GABARAP), microtubule- associated protein 1 light chain 3B (LC3B) and autophagic-related protein 3 (ATG3), and down-regulated the cell-cycle checkpoint control RAD9 homologue B (RAD9B) gene.
Citral, a component of lemongrass oil, activates PPARα and γ and suppresses COX-2 expression.
Functional expression of miraculin, a taste-modifying protein in Escherichia coli.
TLDR
It is shown that recombinant miraculin expressed in E. coli has taste-modifying properties as a homodimer, not as a monomer, indicating that glycosylation is not essential for the taste- modifying property.
DHA attenuates postprandial hyperlipidemia via activating PPARα in intestinal epithelial cells[S]
TLDR
It is suggested that DHA can inhibit the secretion of TG from intestinal epithelial cells via PPARα activation, which attenuates postprandial hyperlipidemia.
Resveratrol Targets in Inflammation.
  • H. Inoue, R. Nakata
  • Biology
    Endocrine, metabolic & immune disorders drug…
  • 31 August 2015
TLDR
It is hypothesized that there is a molecular basis for the mutually beneficial relationship between plants and humans, which is important for understanding the mode of action of resveratrol in inflammation.
Vaticanol C, a resveratrol tetramer, activates PPARα and PPARβ/δ in vitro and in vivo
TLDR
Findings indicate that activation of PPARα and PPARβ/δ by vaticanol C may be a novel mechanism, affording beneficial effects against lifestyle-related diseases.
Skipping breakfast adversely affects menstrual disorders in young college students
TLDR
It is suggested that skipping breakfast adversely affects menstrual disorders in young college students.
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