• Publications
  • Influence
Carvacrol, a component of thyme oil, activates PPARα and γ and suppresses COX-2 expression[S]
Cyclooxygenase-2 (COX-2), the rate-limiting enzyme in prostaglandin biosynthesis, plays a key role in inflammation and circulatory homeostasis. Peroxisome proliferator-activated receptors (PPARs) areExpand
  • 177
  • 12
  • PDF
Two different promoters direct expression of two distinct forms of mRNAs of human platelet‐activating factor receptor
The human platelet‐activating factor (PAF) receptor gene exists as a single copy on chromosome 1. We identified two 5′‐noncoding exons, each of which has distinct transcriptional initiation sites.Expand
  • 94
  • 6
Recent advances in the study on resveratrol.
Appropriate long-term drinking of red wine is associated with a reduced risk for lifestyle-related diseases such as cardiovascular disease and cancer, making resveratrol, a constituent of grapes andExpand
  • 121
  • 6
  • PDF
Farnesol, an isoprenoid, improves metabolic abnormalities in mice via both PPARα-dependent and -independent pathways.
  • T. Goto, Y. Kim, +12 authors T. Kawada
  • Biology, Medicine
  • American journal of physiology. Endocrinology and…
  • 1 November 2011
Peroxisome proliferator-activated receptors (PPARs) control energy homeostasis. In this study, we showed that farnesol, a naturally occurring ligand of PPARs, could ameliorate metabolic diseases.Expand
  • 40
  • 4
  • PDF
Up-regulation of endothelial nitric oxide synthase (eNOS), silent mating type information regulation 2 homologue 1 (SIRT1) and autophagy-related genes by repeated treatments with resveratrol in human
Resveratrol, a polyphenolic phytoalexin found in red wine and various plants, has been reported to up-regulate the expression of endothelial NO synthase (eNOS) in human umbilical vein endothelialExpand
  • 32
  • 4
  • PDF
Accumulation of quercetin conjugates in blood plasma after the short-term ingestion of onion by women.
Quercetin is a typical flavonoid present mostly as glycosides in plant foods; it has attracted much attention for its potential beneficial effects in disease prevention. In this study, we examinedExpand
  • 174
  • 3
  • PDF
Vaticanol C, a resveratrol tetramer, activates PPARα and PPARβ/δ in vitro and in vivo
BackgroundAppropriate long-term drinking of red wine is associated with a reduced risk of cardiovascular disease. Resveratrol, a well-known SIRT1 activator is considered to be one of the beneficialExpand
  • 38
  • 3
Functional expression of miraculin, a taste-modifying protein in Escherichia coli.
Miraculin isolated from red berries of Richadella dulcifica, a native shrub of West Africa, has the unusual property of modifying a sour taste into a sweet one. This homodimer protein consists of twoExpand
  • 23
  • 3
Citral, a component of lemongrass oil, activates PPARα and γ and suppresses COX-2 expression.
Lemongrass is a widely used herb as a food flavoring, as a perfume, and for its analgesic and anti-inflammatory purposes; however, the molecular mechanisms of these effects have not been elucidated.Expand
  • 92
  • 2
DHA attenuates postprandial hyperlipidemia via activating PPARα in intestinal epithelial cells[S]
It is known that peroxisome proliferator-activated receptor (PPAR)α, whose activation reduces hyperlipidemia, is highly expressed in intestinal epithelial cells. Docosahexaenoic acid (DHA) couldExpand
  • 29
  • 2
  • PDF