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Rare and common variants in CARD14, encoding an epidermal regulator of NF-kappaB, in psoriasis.
TLDR
Fifteen additional rare missense variants in CARD14 are described, their distribution in seven psoriasis cohorts, and their effects on NF-kB activation and the transcriptome of keratinocytes, to contribute to the understanding of the genetic basis of Psoriasis and illustrate the challenges faced in identifying pathogenic variants in common disease. Expand
Genomewide Scan Reveals Association of Psoriasis with IL-23 and NF-κB Pathways
TLDR
The results provide strong support for the association of at least seven genetic loci and psoriasis (each with combined P < 5 × 10−8) and suggest priority targets for study in other auto-immune disorders. Expand
Evidence for two psoriasis susceptibility loci (HLA and 17q) and two novel candidate regions (16q and 20p) by genome-wide scan.
TLDR
This genome-wide scan identifies a psoriasis susceptibility locus at HLA, confirms linkage to 17q, and recommends two novel genomic regions for further scrutiny, one of these regions (16q) overlaps with a recently-identified susceptibility loci for Crohn's disease. Expand
Sequence and haplotype analysis supports HLA-C as the psoriasis susceptibility 1 gene.
TLDR
Results strongly suggest that HLA-Cw6 is the PSORS1 risk allele that confers susceptibility to early-onset psoriasis. Expand
Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2
TLDR
A genome-wide association analysis of 2,339,118 SNPs in 472 PsV cases and 1,146 controls from Germany suggests that TRAF3IP2 represents a shared susceptibility for PsV and PsA. Expand
Deletion of the late cornified envelope LCE3B and LCE3C genes as a susceptibility factor for psoriasis
TLDR
LCE expression can be induced in normal epidermis by skin barrier disruption and is strongly expressed in psoriatic lesions, suggesting that compromised skin barrier function has a role in psoriasis susceptibility. Expand
Association analyses identify six new psoriasis susceptibility loci in the Chinese population
TLDR
Six new susceptibility loci associated with psoriasis in the Chinese study containing the candidate genes ERAP1, PTTG1, CSMD1, GJB2, SERPINB8 and ZNF816A are identified and the heterogeneity of disease susceptibility between the Chinese and European populations is highlighted. Expand
Genome-wide association analysis identifies three psoriasis susceptibility loci
TLDR
A meta-analysis of two recent psoriasis genome-wide association studies with a combined discovery sample of 1,831 affected individuals and 2,546 controls identified three new susceptibility loci, including one at NOS2, one at FBXL19 and one near PSMA6-NFKBIA. Expand
Assessment of the psoriatic transcriptome in a large sample: additional regulated genes and comparisons with in vitro models.
TLDR
This comprehensive analysis of differentially regulated transcripts in psoriasis provides additional insight into the pathogenic mechanisms involved and emphasizes the need for more complex yet tractable experimental models of psoriatic disease. Expand
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