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Dysfunction of store-operated calcium channel in muscle cells lacking mg29
The slow cumulative calcium entry through SOC is crucial for long-term calcium homeostasis, such that reduced SOC activity exaggerates muscle fatigue under conditions of intensive exercise. Expand
Interaction of antimicrobial peptides with biological and model membranes: structural and charge requirements for activity.
Structural and charge requirements for the interaction of endogenous antimicrobial peptides and short peptides that have been derived from them, with membranes are discussed. Expand
Requirements for antibacterial and hemolytic activities in the bovine neutrophil derived 13‐residue peptide indolicidin
The antimicrobial and hemolytic activities of the 13‐residue peptide indolicidin (ILPWKWPWWPWRR‐NH2), present in bovine neutrophils, and its analogs have been determined with a view to gainingExpand
Induction of autophagic cell death in Leishmania donovani by antimicrobial peptides.
Results indicate that in addition to their effects on the leishmanial membrane, these antimicrobial peptides induce pathway(s) for autophagic cell death in L. donovani. Expand
Biological activities of C‐terminal 15‐residue synthetic fragment of melittin: design of an analog with improved antibacterial activity
An analog of MCF, MCFA, in which two cationic residues have been trans‐positioned to the N‐terminal region from the C‐terminAL region, exhibits antibacterial activity comparable to that of melittin, but is only marginally more hemolytic than MCF. Expand
Antifungal Activities of Human Beta-Defensins HBD-1 to HBD-3 and Their C-Terminal Analogs Phd1 to Phd3
The activities of defensins HBD-1, HBD2, and HBD3 and their C-terminal analogs Phd1, Phd 2, and Phd3 against Candida albicans were investigated and it was indicated that the initial site of action was the fungal membrane. Expand
RyR3 Amplifies RyR1-mediated Ca2+-induced Ca2+ Release in Neonatal Mammalian Skeletal Muscle*
  • Dongmei Yang, Z. Pan, +4 authors Heping Cheng
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 26 October 2001
It is demonstrated that RyR1 participates in both VICR and Ca2+-induced Ca 2+release (CICR) and thatRyR3 amplifies RyR3-mediated CICR in neonatal skeletal muscle and can serve important roles in Ca2- signaling of cell differentiation and muscle contraction. Expand
Cell-lytic and antibacterial peptides that act by perturbing the barrier function of membranes: facets of their conformational features, structure-function correlations and membrane-perturbing
Although molecules like vancomycin, bacitracin and penicillins have been extensively used as antibiotics for therapeutic purposes, most species throughout the evolutionary scale use peptides as antimicrobial agents. Expand
Host-defense antimicrobial peptides: importance of structure for activity.
The structures of host defence antibacterial peptides and the structural requirements for activity are reviewed and there is considerable variation in their primary structures, length and number of positive charges. Expand
Antibacterial activities and conformations of synthetic alpha-defensin HNP-1 and analogs with one, two and three disulfide bridges.
  • M. Mandal, R. Nagaraj
  • Chemistry, Medicine
  • The journal of peptide research : official…
  • 1 March 2002
Although the S-S connectivities observed in HNP-1 may be necessary for other physiological activities, such as chemotaxis, they are clearly not essential for antibacterial activity. Expand