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Ketorolac. A reappraisal of its pharmacodynamic and pharmacokinetic properties and therapeutic use in pain management.
Ketorolac is a strong analgesic with a tolerability profile which resembles that of other NSAIDs when used in accordance with current dosage guidelines, this drug provides a useful alternative, or adjuvant, to opioids in patients with moderate to severe pain.
Midazolam. A review of its pharmacological properties and therapeutic use.
A combination of properties make midazolam a useful addition to the benzodiazepine group, useful for anaesthetic induction in poor-risk, elderly and cardiac patients and suitable for long term infusion as a sedative and amnestic for intensive care.
Gliclazide. An update of its pharmacological properties and therapeutic efficacy in non-insulin-dependent diabetes mellitus.
Gliclazide is an effective agent for the treatment of the metabolic defects associated with NIDDM and may have the added advantage of potentially slowing the progression of diabetic retinopathy.
Metoclopramide. An updated review of its pharmacological properties and clinical use.
- R. Harrington, C. Hamilton, R. N. Brogden, J. Linkewich, J. Romankiewicz, R. Heel
- 1 May 1983
Metoclopramide has been confirmed as an effective drug in treating and preventing various types of vomiting and as a useful agent in oesophageal reflux disease, gastroparesis, dyspepsia, and in a variety of functional gastrointestinal disorders.
Naltrexone. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy in the management of opioid dependence.
Despite the overall high attrition rates from trials, in selected patient groups and in combination with appropriate support mechanisms and psychotherapy, naltrexone represents a useful adjunct for the maintenance of abstinence in the detoxified opioid addict.
Mefloquine. A review of its antimalarial activity, pharmacokinetic properties and therapeutic efficacy.
Mefloquine is generally well tolerated in both adults and children, with nausea, vomiting, diarrhoea, headache, dizziness, rash, pruritus and abdominal pain being the most common adverse effects, although it is difficult to distinguish between disease- and treatment-related events.
Meropenem. A review of its antibacterial activity, pharmacokinetic properties and clinical efficacy.
Meropenem is an effective broad spectrum antibacterial drug for the treatment of a wide range of infections including polymicrobial infections in both adults and children, with comparable efficacy to imipenem/cilastatin and various other treatment regimens.
Nimesulide. An update of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy.
Nimesulide is a nonsteroidal anti-inflammatory drug (NSAID) administered orally or rectally twice daily for a variety of inflammatory and pain states. In mostly short term studies (up to 4 weeks), it…
Ketorolac. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential.
Ketorolac offers promise as an alternative to opioid and to other nonsteroidal analgesics in ameliorating moderate to severe postsurgical pain, and with wider clinical experience may find a place in the treatment of acute musculoskeletal and other pain states, and ocular inflammatory conditions.
Liposomal amphotericin B. Therapeutic use in the management of fungal infections and visceral leishmaniasis.
Liposomal amphotericin B is an effective treatment for visceral leishmaniasis in immunocompetent adults and children, including those with severe or drug-resistant disease and the drug also produces good response rates in Immunocompromised patients; however, relapse rates in these patients are high.