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Metoclopramide. An updated review of its pharmacological properties and clinical use.
TLDR
Metoclopramide has been confirmed as an effective drug in treating and preventing various types of vomiting and as a useful agent in oesophageal reflux disease, gastroparesis, dyspepsia, and in a variety of functional gastrointestinal disorders. Expand
Midazolam. A review of its pharmacological properties and therapeutic use.
TLDR
A combination of properties make midazolam a useful addition to the benzodiazepine group, useful for anaesthetic induction in poor-risk, elderly and cardiac patients and suitable for long term infusion as a sedative and amnestic for intensive care. Expand
Ketorolac. A reappraisal of its pharmacodynamic and pharmacokinetic properties and therapeutic use in pain management.
TLDR
Ketorolac is a strong analgesic with a tolerability profile which resembles that of other NSAIDs when used in accordance with current dosage guidelines, this drug provides a useful alternative, or adjuvant, to opioids in patients with moderate to severe pain. Expand
Naltrexone. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy in the management of opioid dependence.
TLDR
Despite the overall high attrition rates from trials, in selected patient groups and in combination with appropriate support mechanisms and psychotherapy, naltrexone represents a useful adjunct for the maintenance of abstinence in the detoxified opioid addict. Expand
Gliclazide. An update of its pharmacological properties and therapeutic efficacy in non-insulin-dependent diabetes mellitus.
TLDR
Gliclazide is an effective agent for the treatment of the metabolic defects associated with NIDDM and may have the added advantage of potentially slowing the progression of diabetic retinopathy. Expand
Meropenem. A review of its antibacterial activity, pharmacokinetic properties and clinical efficacy.
TLDR
Meropenem is an effective broad spectrum antibacterial drug for the treatment of a wide range of infections including polymicrobial infections in both adults and children, with comparable efficacy to imipenem/cilastatin and various other treatment regimens. Expand
Nimesulide. An update of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy.
Nimesulide is a nonsteroidal anti-inflammatory drug (NSAID) administered orally or rectally twice daily for a variety of inflammatory and pain states. In mostly short term studies (up to 4 weeks), itExpand
Mefloquine. A review of its antimalarial activity, pharmacokinetic properties and therapeutic efficacy.
TLDR
Mefloquine is generally well tolerated in both adults and children, with nausea, vomiting, diarrhoea, headache, dizziness, rash, pruritus and abdominal pain being the most common adverse effects, although it is difficult to distinguish between disease- and treatment-related events. Expand
Liposomal amphotericin B. Therapeutic use in the management of fungal infections and visceral leishmaniasis.
TLDR
Liposomal amphotericin B is an effective treatment for visceral leishmaniasis in immunocompetent adults and children, including those with severe or drug-resistant disease and the drug also produces good response rates in Immunocompromised patients; however, relapse rates in these patients are high. Expand
Diltiazem. A review of its pharmacological properties and therapeutic efficacy.
TLDR
Diltiazem offers a worthwhile alternative to other agents currently available for the treatment of angina pectoris and although the infrequency of serious side effects may offer an advantage, its relative place in therapy compared with that of other calcium channel blockers remains to be clarified. Expand
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