• Publications
  • Influence
Inactivation of enveloped viruses by anthraquinones extracted from plants
TLDR
Aloe emodin inactivated all of the viruses tested except adenovirus and rhinovirus, showing that anthraquinones extracted from a variety of plants are directly virucidal to enveloped viruses. Expand
South American plants II: taspine isolation and anti-inflammatory activity.
TLDR
Croton lechleri L. (Euphorbiaceae), a plant from the Upper Amazon Valley of Peru, yielded the alkaloid taspine, which was studied using the carrageenan-induced pedal edema method, the cotton pellet-induced granuloma method, and the adjuvant polyarthritis model. Expand
PERICYCLIVINE, A NEW CATHARANTHUS ALKALOID.
Structure Elucidation and Chemistry of Catharanthus Alkaloids II. Isolation and Partial Structure of Catharine, a Dimeric Indole Alkaloid From C. Zanceus and C. Roseus
A continuing study of Catharanthus lanceus alkaloid fractions, in a search for new antineoplastic alkaloids, has led to the isolation of Catharine, a dimeric indole alkaloid found previously only inExpand
Catharanthus lanceus VII. Isolation of tetrahydroalstonine, lochnerinine, and periformyline.
TLDR
Details concerning the isolation of tetrahydroalstonine, lochnerinine, and the structure elucidation of periformyline, the first example of an N (b) -substituted formyl indole alkaloid to be found in nature, are presented. Expand
Catharanthus alkaloids. 13. Antineoplastic and hypotensive activity of alkaloid fractions and certain alkaloids from Catharanthus lanceus.
TLDR
Leurosine, isolated from the active fraction, was shown to be a potent antineoplastic alkaloid with a high degree of cytotoxicity, and Lochnerinine, although devoid of activity against the P-1534 leukemia, exhibited reproducible cytot toxicity against the 9 KB cell culture. Expand
Antiviral activity of selected Catharanthus alkaloids.
TLDR
Thirty-six alkaloids isolated either from Catharanthus roseus or C. lanceus were evaluated for in vitro activity against vaccinia and polio type III viruses, with pericalline being the most effective. Expand
South American plants III: Isolation of fulvoplumierin from Himatanthus sucuuba (M. Arg.) Woodson (Apocynaceae).
The bark of Himatanthus sucuuba was screened for pharmacological and anticancer activities. The lactone, fulvoplumierin (C14H12O4), was isolated from the n-hexane fraction. The identity was proven byExpand
...
1
2
3
...