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Structure, function and evolution of sex-determining systems in Dipteran insects.
Nature has evolved an astonishing variety of genetic and epigenetic sex-determining systems which all achieve the same result, the generation of two sexes. Genetic and molecular analyses, mainlyExpand
Sex determination in the germ line of Drosophila depends on genetic signals and inductive somatic factors.
We have analyzed the mechanism of sex determination in the germ line of Drosophila by manipulating three parameters: (1) the ratio of X-chromosomes to sets of autosomes (X:A); (2) the state ofExpand
The sex-determining gene tra-2 of Drosophila encodes a putative RNA binding protein
The gene transformer-2 (tra-2) of Drosophila is necessary not only for female sexual differentiation but also for normal spermatogenesis in males. We have cloned and characterized the tra-2 gene. ItsExpand
Cell-autonomous and inductive signals can determine the sex of the germ line of Drosophila by regulating the gene Sxl
To investigate the mechanism of sex determination in the germ line, we analyzed the fate of XY germ cells in ovaries, and the fate of XX germ cells in testes. In ovaries, germ cells developedExpand
Sex-lethal, the master sex-determining gene in Drosophila, is not sex-specifically regulated in Musca domestica.
Sex-lethal (Sxl) is the master switch gene for somatic sex determination in Drosophila melanogaster. In XX animals, Sxl becomes activated and imposes female development; in X(Y) animals, Sxl remainsExpand
The evolution of the Drosophila sex-determination pathway.
The molecular complexity of the Drosophila somatic sex-determination pathway poses formidable intellectual challenges for attempts to explain its evolutionary origins. Here we present aExpand
Alternatively spliced transcripts of the sex‐determining gene tra‐2 of Drosophila encode functional proteins of different size.
The Drosophila transformer‐2 gene (tra‐2) is required for female sex determination in somatic cells and for spermatogenesis in male germ cells. We studied the organization of the tra‐2 gene andExpand
The male-determining activity on the Y chromosome of the housefly (Musca domestica L.) consists of separable elements.
In the common housefly, the presence or absence of a male-determining factor, M, is responsible for sex determination. In different strains, M has been found on the Y, on the X, or on any of the fiveExpand
Developmental analysis of two sex-determining genes, M and F, in the housefly, Musca domestica.
In the housefly, Musca domestica, a single dominant factor, M, determines maleness. Animals hemi-or heterozygous for M are males, whereas those without M develop as females. In certain strains,Expand
Sex determination and dosage compensation in Drosophila melanogaster: production of male clones in XX females
Sex determination and dosage compensation in Drosophila are implemented by the ratio of X‐chromosomes to sets of autosomes (X:A ratio). Our aim was to change this X:A ratio during development, and toExpand