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Injection of solutions into cerebral tissue: Relation between volume and diffusion
Abstract The relationship between the extent of diffusion of a solution and the volume injected has been investigated for cerebral tissue in anesthetized rats. Each of four dyes of unequal molecularExpand
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14C-dopamine microinjected into the brain-stem of the rat: Dispersion kinetics, site content and functional dose
A morphological analysis was undertaken of both the dispersion characteristics and tissue content of dopamine (DA) microinjected acutely into the brain-stem of the anesthetized rat. 14C-DA, with aExpand
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Micro-injection of 3H-acetylcholine, 14C-serotonin and 3H-norepinephrine into the hypothalamus of the rat: diffusion into tissue and ventricles.
Abstract In order to specify more clearly the action of a chemical substance in eliciting ingestive or other behavioral responses, the spread of the candidate transmitters acetylcholine (ACh),Expand
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Antisense to NPY-Y1 demonstrates that Y1 receptors in the hypothalamus underlie NPY hypothermia and feeding in rats
Neuropeptide Y (NPY) is a highly potent endogenous peptide which when injected into the medial hypothalamus causes spontaneous eating behaviour and an intense fall in body temperature (Tb). ThisExpand
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Action of harman (1-methyl-β-carboline) on the brain: Body temperature and in vivo efflux of 5-HT from hippocampus of the rat
Harman (1-methyl-beta-carboline) has been shown previously to act on the hippocampus of the rat in terms of its evocation of anxiogenic responses and induction of alcohol preference. In the presentExpand
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Drinking of high concentrations of ethanol versus palatable fluids in alcohol-preferring (P) rats: valid animal model of alcoholism.
A genetically based animal model of alcoholism has been characterized in Wistar-derived rats in terms of their preference (P rats) or lack of preference (NP rats) for 10% ethanol over water. TheExpand
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Genetic differences in ethanol drinking of the rat following injection of 6-OHDA, 5,6-DHT or 5,7-DHT into the cerebral ventricles
The preference characteristics for ethanol of four different strains of rats were determined in a two-choice situation by offering water and ethanol in a concentration which was increased from 3 toExpand
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Dopamine and thermoregulation: An evaluation with special reference to dopaminergic pathways
The complex role of dopamine (DA) in the diencephalic mechanisms involved in the control of body temperature is reviewed and evaluated. In the context of the monoamine theory of thermoregulation,Expand
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2-Deoxy-D-glucose and insulin modify release of norepinephrine from rat hypothalamus.
Both 2-deoxy-D-glucose (2-DG) and insulin, administered systemically, evoke spontaneous feeding in the satiated animal. To determine whether hypothalamic norepinephrine (NE) could be involved in thisExpand
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In vivo acetaldehyde in the brain of the rat treated with ethanol.
Abstract Ethanol, 4.5 g/kg, was administered intragastrically to rats to determine if acetaldehyde could be detected in brain interstitial fluid. Samples from both blood and brain were collected atExpand
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