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Pathogenesis of sciatic pain: role of herniated nucleus pulposus and deformation of spinal nerve root and dorsal root ganglion
Abstract The basic pathophysiologic mechanisms related to disc herniation and sciatica are poorly understood. Recently it was demonstrated that nucleus pulposus from an intervertebral disc couldExpand
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Exogenous Tumor Necrosis Factor-Alpha Mimics Nucleus Pulposus-Induced Neuropathology: Molecular, Histologic, and Behavioral Comparisons in Rats
Study Design. This study tested the hypothesis that the 17-kDa form of tumor necrosis factor-alpha is the pathophysiologic agent expressed by herniated nucleus pulposus in vivo that is primarilyExpand
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An in vitro mechanical and histological study of acute stretching on rabbit tibial nerve
Peripheral nerves are often mechanically stretched in association with trauma to extremities, resulting in varying degrees of impairment of nerve function. However, little is known about theExpand
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Injury Type-Specific Calcium Channel α2δ-1 Subunit Up-Regulation in Rat Neuropathic Pain Models Correlates with Antiallodynic Effects of Gabapentin
The calcium channel α2δ-1 subunit is a structural subunit important for functional calcium channel assembly. In vitro studies have shown that this subunit is the binding site for gabapentin, anExpand
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TNF-alpha and TNF-alpha receptor type 1 upregulation in glia and neurons after peripheral nerve injury: studies in murine DRG and spinal cord.
OBJECTIVES The purpose of the current study was to evaluate changes in tumor necrosis factor-alpha (TNF-alpha ) and TNF-alpha receptor 1 (p55 receptor) using double fluorescent immunohistochemistryExpand
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TNF-&agr; and TNF-&agr; Receptor Type 1 Upregulation in Glia and Neurons After Peripheral Nerve Injury: Studies in Murine DRG and Spinal Cord
Objectives. The purpose of the current study was to evaluate changes in tumor necrosis factor-&agr; (TNF-&agr;) and TNF-&agr; receptor 1 (p55 receptor) using double fluorescent immunohistochemistryExpand
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Anti-inflammatory interleukin-10 therapy in CCI neuropathy decreases thermal hyperalgesia, macrophage recruitment, and endoneurial TNF-α expression
&NA; The chronic constriction injury model of mononeuropathy is a direct, partial nerve injury yielding thermal hyperalgesia. The inflammation that results from this injury is believed to contributeExpand
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Upregulation and interaction of TNFα and gelatinases A and B in painful peripheral nerve injury
Chronic constriction injury (CCI) to peripheral nerve causes a painful neuropathy in association with a process of axonal degeneration and endoneural remodeling that involves macrophage recruitmentExpand
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Endoneurial injection of TNF-α produces neuropathic pain behaviors
THE inflammatory component of peripheral nerve injury may affect the development of local neuropathologic changes as well as the onset of hyperalgesia, the characteristic features of experimentalExpand
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Cytokine regulation of MMP-9 in peripheral glia: Implications for pathological processes and pain in injured nerve
Matrix metalloproteinase-9 (MMP-9) is an extracellular protease that is induced in Schwann cells hours after peripheral nerve injury and controls axonal degeneration and macrophage recruitment to theExpand
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