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Investigating biological activity spectrum for novel quinoline analogues.
The structure-activity relationships (SAR) between the chemical structure and biological effects of the synthesized compounds are described and the relationships between the RP-HPLC retention parameter logK (the logarithm of capacity factor K) and logP data calculated by available programs are illustrated. Expand
Antifungal properties of new series of quinoline derivatives.
The correlation between RP-HPLC retention parameter log K (the logarithm of capacity factor K) and various calculated log P data is shown and the relationships between the lipophilicity and the chemical structure of the studied compounds are discussed as well. Expand
An overview of quinoline as a privileged scaffold in cancer drug discovery
  • R. Musiol
  • Chemistry, Medicine
  • Expert opinion on drug discovery
  • 20 April 2017
The quinoline moiety offers an easily accessible, well-understood scaffold for designing new drugs, and is also a very druggable molecule with the potency for structure optimization through established synthetic pathways, which has a strong position in modern medicinal chemistry. Expand
Pyrrolidinium-Based Ionic Liquids as Sustainable Media in Heat-Transfer Processes
Ionic liquids are viewed as green media for many engineering applications and exhibit exceptional properties, including negligible vapor pressure, null flammability, wide liquid range, and highExpand
Contribution to investigation of antimicrobial activity of styrylquinolines.
Series of new ring-substituted styrylquinolines and two oxorhenium complexes prepared and characterized expressed excellent antifungal activity and antibacterial activity against Staphylococcus strains comparable with or higher than the standards bacitracin, penicillin and ciprofloxacin. Expand
Azole antimycotics--a highway to new drugs or a dead end?
The era of azole fungicides began with the breakthrough of chlormidazole roughly 50 years ago and more than 20 drugs of this group, including triazoles, have been brought to the market. Expand
An Efficient Microwave-Assisted Synthesis of Structurally Diverse Styrylquinolines
Summary.Aromatic aldehydes undergo condensation with quinaldines under microwave irradiation to afford structurally diverse styrylquinolines in high yields under solvent-free conditions. A comparisonExpand
Prodrugs in photodynamic anticancer therapy.
Photodynamic therapy (PDT), the concept of cancer treatment through the selective uptake of a light-sensitive agent followed by exposure to a specific wavelength, is limited by the transport of aExpand
Spectroscopic (FT-IR, FT-Raman) investigations and quantum chemical calculations of 4-hydroxy-2-oxo-1,2-dihydroquinoline-7-carboxylic acid.
The stability of the molecule arising from hyperconjugative interaction and charge delocalization has been analyzed using NBO analysis and the calculated geometrical parameters are in agreement with that of similar derivatives. Expand
Quinoline-based antifungals.
This current review is focused on the recent findings in the design of quinoline based antifungal agents, as 8-hydroxyquinoline and its metal complexes have been well known as antIfungals for years. Expand