Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant
- P. Willner, A. Towell, D. Sampson, S. Sophokleous, R. Muscat
- Psychology, BiologyPsychopharmacology
Rats exposed chronically to a variety of mild unpredictable stressors showed a reduced consumption of and preference for saccharin or sucrose solutions and DMI reduced blood corticosterone and glucose levels, but stress did not significantly alter either measure.
Chronic mild stress-induced anhedonia: A realistic animal model of depression
An animal model of anhedonia: attenuation of sucrose consumption and place preference conditioning by chronic unpredictable mild stress
Chronic exposure to very mild unpredictable stress has previously been found to depress the consumption of, and preference for, highly palatable sweet solutions, but appears to cause a generalized decrease in sensitivity to rewards.
Oligodendrocyte Pathophysiology and Treatment Strategies in Cerebral Ischemia
- Gabriella Mifsud, C. Zammit, R. Muscat, G. Di Giovanni, M. Valentino
- BiologyCNS Neuroscience & Therapeutics
- 1 July 2014
The OL is a primary target of ischemia in adult‐onset stroke and especially in periventricular leukomalacia and should be considered as a primary therapeutic target in these conditions.
Reversal of stress-induced anhedonia by the atypical antidepressants, fluoxetine and maprotiline
Previous reports of the efficacy of tricyclic antidepressants in this paradigm are extended, and support the hypothesis of a dopaminergic mechanism of antidepressant action.
The central role of aquaporins in the pathophysiology of ischemic stroke
- J. Vella, C. Zammit, G. Di Giovanni, R. Muscat, M. Valentino
- BiologyFrontiers in Cellular Neuroscience
- 8 April 2015
In models of vasogenic edema, brain swelling is more pronounced in AQP4-null mice than wild-type providing strong evidence of the dual role of AQP 4 in the formation and resolution of both vasogenic and cytotoxic edema.
Attenuation of place preference conditioning but not place aversion conditioning by chronic mild stress
- M. Papp, Spiros Lappas, R. Muscat, P. Willner
- Biology, PsychologyJournal of Psychopharmacology
- 1 May 1992
The results demonstrate that chronic stress does not cause a general impairment of associative learning but, rather, a specific impairment of rewarded behaviour.
Reversal of stress-induced anhedonia by the dopamine receptor agonist, pramipexole
The results indicate that pramipexole exerts rapid anti-anhedonic effects in the chronic mild stress model, and is complicated, but not undermined, by drug-induced weight loss and by the presence of significant drug effects in nonstressed control animals.
Environmental influences on behavioural sensitization to the dopamine agonist quinpirole
The results suggest that the extent of sensitization to quinpirole is determined by the behaviour elicited by the drug, rather than the environment in which it is administered, which is proposed to account for these effects.
Effects of dopamine receptor antagonists on sucrose consumption and preference
The effects of antagonizing either subtype of DA receptor appear to be similar to those of reducing the concentration of sucrose.