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Biological Insights From 108 Schizophrenia-Associated Genetic Loci
Associations at DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses. Expand
Cannabis use in adolescence and risk for adult psychosis: longitudinal prospective study
This is the first prospective longitudinal study of adolescent cannabis use as a risk factor for adult schizophreniform disorder, taking into account childhood psychotic symptoms, and the Dunedin multidisciplinary health and development study has a 96% follow up rate at age 26. Expand
Meta-analysis of regional brain volumes in schizophrenia.
OBJECTIVE The authors' goal was to determine whether patients with schizophrenia differ from comparison subjects in regional brain volumes and whether these differences are similar in male and femaleExpand
Genome-wide Association Analysis Identifies 14 New Risk Loci for Schizophrenia
It is estimated that 8,300 independent, mostly common SNPs contribute to risk for schizophrenia and that these collectively account for at least 32% of the variance in liability. Expand
Symmetries in human brain language pathways correlate with verbal recall
It is suggested that the degree of lateralization of perisylvian pathways is heterogeneous in the normal population and, paradoxically, bilateral representation, not extreme lateralization, might ultimately be advantageous for specific cognitive functions. Expand
Common variants conferring risk of schizophrenia
Findings implicating the MHC region are consistent with an immune component to schizophrenia risk, whereas the association with NRGN and TCF4 points to perturbation of pathways involved in brain development, memory and cognition. Expand
Children's self-reported psychotic symptoms and adult schizophreniform disorder: a 15-year longitudinal study.
These findings provide the first evidence for continuity of psychotic symptoms from childhood to adulthood, and the link between child and adult psychotic symptoms was not the result of general childhood psychopathology. Expand
Obstetric complications and schizophrenia: historical and meta-analytic review.
Current methods of investigating the relationship between obstetric complications and schizophrenia are reaching the limit of their usefulness, and a combination of disciplines and approaches will be needed to elucidate the mechanisms underlying these small but important associations. Expand
Atlasing location, asymmetry and inter-subject variability of white matter tracts in the human brain with MR diffusion tractography
It is suggested that DTI-derived maps can be used together with a previous histological atlas to establish the relationship of focal lesions with nearby tracts and improve clinico-anatomical correlation. Expand
Prevalence and correlates of self-reported psychotic symptoms in the British population
Self-reported psychotic symptoms are less common in this study than reported elsewhere, because of the measure used, but these symptoms have demographic and clinical correlates similar to clinical psychosis. Expand