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Biological Insights From 108 Schizophrenia-Associated Genetic Loci
Associations at DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses.
Cannabis use in adolescence and risk for adult psychosis: longitudinal prospective study
- L. Arseneault, M. Cannon, R. Poulton, R. Murray, A. Caspi, T. Moffitt
- Psychology, MedicineBMJ : British Medical Journal
- 23 November 2002
This is the first prospective longitudinal study of adolescent cannabis use as a risk factor for adult schizophreniform disorder, taking into account childhood psychotic symptoms, and the Dunedin multidisciplinary health and development study has a 96% follow up rate at age 26.
Meta-analysis of regional brain volumes in schizophrenia.
- I. Wright, S. Rabe-Hesketh, P. Woodruff, A. David, R. Murray, E. Bullmore
- Psychology, MedicineThe American journal of psychiatry
OBJECTIVE The authors' goal was to determine whether patients with schizophrenia differ from comparison subjects in regional brain volumes and whether these differences are similar in male and female…
Genome-wide Association Analysis Identifies 14 New Risk Loci for Schizophrenia
It is estimated that 8,300 independent, mostly common SNPs contribute to risk for schizophrenia and that these collectively account for at least 32% of the variance in liability.
Common variants conferring risk of schizophrenia
Findings implicating the MHC region are consistent with an immune component to schizophrenia risk, whereas the association with NRGN and TCF4 points to perturbation of pathways involved in brain development, memory and cognition.
Obstetric complications and schizophrenia: historical and meta-analytic review.
Current methods of investigating the relationship between obstetric complications and schizophrenia are reaching the limit of their usefulness, and a combination of disciplines and approaches will be needed to elucidate the mechanisms underlying these small but important associations.
Symmetries in human brain language pathways correlate with verbal recall
- M. Catani, M. Allin, Derek K. Jones
- Psychology, BiologyProceedings of the National Academy of Sciences
- 23 October 2007
It is suggested that the degree of lateralization of perisylvian pathways is heterogeneous in the normal population and, paradoxically, bilateral representation, not extreme lateralization, might ultimately be advantageous for specific cognitive functions.
Children's self-reported psychotic symptoms and adult schizophreniform disorder: a 15-year longitudinal study.
- R. Poulton, A. Caspi, T. Moffitt, M. Cannon, R. Murray, H. Harrington
- Psychology, MedicineArchives of general psychiatry
- 1 November 2000
These findings provide the first evidence for continuity of psychotic symptoms from childhood to adulthood, and the link between child and adult psychotic symptoms was not the result of general childhood psychopathology.
Large recurrent microdeletions associated with schizophrenia
In a genome-wide search for CNVs associating with schizophrenia, a population-based sample was used to identify de novo CNVs by analysing 9,878 transmissions from parents to offspring and three deletions significantly associate with schizophrenia and related psychoses in the combined sample.