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Quantitative structure-activity relationship of sesquiterpene lactones as inhibitors of the transcription factor NF-kappaB.
TLDR
This work investigates a set of 103 different sesquiterpene lactones representing 6 structural groups for their NF-kappaB inhibiting properties and the resulting IC(100)-values were submitted to a QSAR study.
Inhibition of the transcription factor NF-kappa B by sesquiterpene lactones from Podachaenium eminens.
TLDR
Although the majority of the Sls tested in this study were monofunctional only low concentrations of 50 microM were often needed for complete inhibition, except for podachaenin, which completely inhibited NF-kappa B DNA binding in an electrophoretic mobility shift assay at concentrations between 5 and 200 microM without showing any cytotoxic effects.
Sesquiterpene lactones from Montanoa hibiscifolia that inhibit the transcription factor NF-kappa B.
The reinvestigation of the aerial parts of Montanoa hibiscifolia afforded four new eudesmanolides (1-4), three of them with a rare endoperoxide structural element and the fourth with a rare carbonyl
Four New Flavonol Glycosides from the Leaves of Brugmansia suaveolens
TLDR
Four new flavonol glycosides were isolated from the leaves of Brugmansia suaveolens and the structure elucidation was performed by MS, 1D and 2D NMR analyses.
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