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Genomic mining for Aspergillus natural products.
3-Desoxyanthocyanidins from Arrabidaea chica.
In vitro studies to evaluate the wound healing properties of Calendula officinalis extracts.
Quantitative structure-activity relationship of sesquiterpene lactones as inhibitors of the transcription factor NF-kappaB.
- B. Siedle, A. García-Piñeres, I. Merfort
- Chemistry, BiologyJournal of medicinal chemistry
- 19 October 2004
This work investigates a set of 103 different sesquiterpene lactones representing 6 structural groups for their NF-kappaB inhibiting properties and the resulting IC(100)-values were submitted to a QSAR study.
In vitro cytotoxic activity of abietane diterpenes from Peltodon longipes as well as Salvia miltiorrhiza and Salvia sahendica.
Inhibitory effects of Piper umbellatum and Piper peltatum extracts towards myotoxic phospholipases A2 from Bothrops snake venoms: isolation of 4-nerolidylcatechol as active principle.
The effect of sesquiterpene lactones on the release of human neutrophil elastase.
Inhibition of the transcription factor NF-kappa B by sesquiterpene lactones from Podachaenium eminens.
Although the majority of the Sls tested in this study were monofunctional only low concentrations of 50 microM were often needed for complete inhibition, except for podachaenin, which completely inhibited NF-kappa B DNA binding in an electrophoretic mobility shift assay at concentrations between 5 and 200 microM without showing any cytotoxic effects.
Sesquiterpene lactones from Montanoa hibiscifolia that inhibit the transcription factor NF-kappa B.
- S. Müller, R. Murillo, V. Castro, V. Brecht, I. Merfort
- ChemistryJournal of natural products
- 17 March 2004
The reinvestigation of the aerial parts of Montanoa hibiscifolia afforded four new eudesmanolides (1-4), three of them with a rare endoperoxide structural element and the fourth with a rare carbonyl…
Four New Flavonol Glycosides from the Leaves of Brugmansia suaveolens
Four new flavonol glycosides were isolated from the leaves of Brugmansia suaveolens and the structure elucidation was performed by MS, 1D and 2D NMR analyses.