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Structural basis for the recognition of guide RNA and target DNA heteroduplex by Argonaute
The 2 Å crystal structure of Rhodobacter sphaeroides Argonaute (RsAgo) in a complex with 18-nucleotide guide RNA and its complementary target DNA is determined and it is shown thatArgonaute discriminates the nucleic acid type (RNA/DNA) by recognition of the duplex structure of the seed region.
Structural basis for the substrate recognition and catalysis of peptidyl-tRNA hydrolase
The crystal structure of Escherichia coli Pth in complex with the tRNA CCA-acceptor-TΨC domain is determined, and an authentic Pth:peptidyl-tRNA complex model and a detailed mechanism for the hydrolysis reaction are proposed, based on the present crystal structure and the previous studies’ results.
n-type organic field-effect transistors with very high electron mobility based on thiazole oligomers with trifluoromethylphenyl groups.
Novel thiazole oligomers and thiazoles/thiophene co-oligomers with trifluoromethylphenyl groups showed excellent n-type performances with high electron mobilities for OFETs.
The Interaction between the Ribosomal Stalk Proteins and Translation Initiation Factor 5B Promotes Translation Initiation
The mutual interaction between a/eIF5B and the ribosomal stalk plays an important role in subunit joining during translation initiation in vivo.
Crystal structure of translation initiation factor 5B from the crenarchaeon Aeropyrum pernix
It is determined that the archaea‐specific region of IF5B (helix α15) binds and occludes the groove of domain IV, which suggests that archaeal IF 5B cannot access IF1A in the same manner as eukaryotic IF5b, and suggests that different relationships between IF5 B and IF1 A exist in archaea and eukARYotes.
Synthesis of primary and secondary alkylboronates through site-selective C(sp3)-H activation with silica-supported monophosphine-Ir catalysts.
The site-selective activation and borylation of unactivated C(sp(3))-H bonds in 2-alkylpyridines to form primary and secondary alkylboronates was achieved using silica-supported monophosphine-Ir
Single-Handed Helical Poly(quinoxaline-2,3-diyl)s Bearing Achiral 4-Aminopyrid-3-yl Pendants as Highly Enantioselective, Reusable Chiral Nucleophilic Organocatalysts in the Steglich Reaction.
The obtained chiral nucleophilic polymer catalysts exhibited high catalytic activity, enantioselectivity, and reusability in asymmetric Steglich rearrangement of oxazolyl carbonate to C-carboxyazlactone.
Chirality-Amplifying, Dynamic Induction of Single-Handed Helix by Chiral Guests to Macromolecular Chiral Catalysts Bearing Boronyl Pendants as Receptor Sites.
The helical macromolecular scaffold whose helicity was thus induced was utilized in palladium-catalyzed asymmetric silaboration of meso-methylenecyclopropane by introducing (diarylphosphino)phenyl pendants at their side chains.
Stereoselective C-H borylations of cyclopropanes and cyclobutanes with silica-supported monophosphane-Ir catalysts.
Heteroatom-directed C-H borylation of cyclopropanes and cyclobutanes was achieved with silica-supported monophosphane-Ir catalysts with exceptional cis stereoselectivity relative to the directing groups.