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Impact of smoking on the frequencies of micronuclei and other nuclear abnormalities in exfoliated oral cells: a comparative study with different cigarette types.
TLDR
The findings suggest that nicotine potentially protects cells against DNA reactive carcinogens contained in tobacco smoke although earlier in vitro and animal studies showed that the alkaloid induces DNA damage per se.
Sea-buckthorn juice protects mice against genotoxic action of cisplatin.
TLDR
SB juice decreased significantly the genotoxic effect of CP at dose of 1.2 mg/kg on somatic (bone marrow) and germ (sperm) cells of mice and at higher dose of the drug the effects was not statistically significant.
Evaluation of amino acids as mediators for the antibacterial activity of iodine-lithium-alpha-dextrin in vitro and in vivo.
TLDR
Systemic application of ILalphaD proved to be successful in the rat infection model by promoting host defence and Probable mechanisms are increased intracellular killing of bacteria by production of hypoiodous acid and iodamines as well as anti-inflammatory activity.
Micronucleus-inducing and antitumor activity of three newly synthesized bridged nitrogen atom-containing pyrimidines.
TLDR
The compound DGS-618 which does not induce MN both in vivo and in vitro and shows antitumor activity in vivo is worth testing in other tumor models.
Relationship between the chemical structures and biological activities (toxicity, mutagenic and antitumor) in newly synthesized derivatives of pyrazolo pyrimidines.
TLDR
The relationship between chemical structure, micronucleus-inducing and antitumor activities was studied in four newly synthesized pyrazolo pyrymidine compounds and it has been shown that only DGB-216 has slight antitUMor activity and increases the mean life span of mice with Ehrlich ascite carcinoma.
Smoking causes induction of micronuclei and other nuclear anomalies in cervical cells.
TLDR
Smoking increased chromosomal instability, cytotoxicity and induced cell divisions in cervical mucosa cells of pre- and post-menopausal women indicating a higher risk for diseases (including cancer) that are causally related to DNA damage.
DNA damage and anti-tumor activity induced by Zn, Ag and Co containing meso- tetra(4-N-oxyethylpyridyl)porphyrins in vivo
In the present study, the activity of the new water-soluble cationic meso-tetra(4-N-oxyethylpyridyl)porphyrin and its Zn, Ag and Co metal derivatives as anti-tumor agents was explored. The tumor was
Investigations of genotoxic activity of the antimicrobial/ antiviral agent FS-1 in rodents by means of the micronucleus and the comet assays
TLDR
The fact that the compound neither induces DNA damage in various organs of mice nor is effective in the induction of MN in bone marrow cells of rats and mice is important for future genotoxicity studies of FS-1, which can be used in clinical medicine after additional testing of safety for humans.
The influence of three newly synthesized pyrimidine-containing compounds on micronucleus induction and tumor growth.
TLDR
These newly synthesized compounds, practically inactive in MN induction and possessing no or slight antitumor activity, increased significantly the mutagenic and antitumors activity of CP, one of the most frequently used chemotherapeutic agents in clinical oncology.
Micronucleus and antitumor activities of two newly synthesized pyrimidine derivatives
TLDR
Two newly synthesized iodides of pyrazolo[1,5a]pyrimidines substantially increase the micronucleus as well as the antitumor activities of cyclophosphamide.
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