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Pantethine rescues a Drosophila model for pantothenate kinase–associated neurodegeneration
Pantothenate kinase–associated neurodegeneration (PKAN), a progressive neurodegenerative disorder, is associated with impairment of pantothenate kinase function. Pantothenate kinase is the firstExpand
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PvdP is a tyrosinase that drives maturation of the pyoverdine chromophore in Pseudomonas aeruginosa.
The iron binding siderophore pyoverdine constitutes a major adaptive factor contributing to both virulence and survival in fluorescent pseudomonads. For decades, pyoverdine production has allowed theExpand
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Analysis of cannabinoids in laser-microdissected trichomes of medicinal Cannabis sativa using LCMS and cryogenic NMR.
Trichomes, especially the capitate-stalked glandular hairs, are well known as the main sites of cannabinoid and essential oil production of Cannabis sativa. In this study the distribution and densityExpand
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Metabolic stereoselectivity of cytochrome P450 3A4 towards deoxypodophyllotoxin: In silico predictions and experimental validation.
Deoxypodophyllotoxin is stereoselectively converted into epipodophyllotoxin by recombinant human cytochrome P450 3A4 (CYP3A4). Further kinetic analysis revealed that the Michaelis-Menten K(m) andExpand
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Perspectives and limits of engineering the isoprenoid metabolism in heterologous hosts
Terpenoids belong to the largest class of natural compounds and are produced in all living organisms. The isoprenoid skeleton is based on assembling of C5 building blocks, but the biosynthesis of aExpand
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The acylase PvdQ has a conserved function among fluorescent Pseudomonas spp.
Pyoverdine biosynthesis in fluorescent Pseudomonas spp. and especially in the opportunistic human pathogen Pseudomonas aeruginosa has been extensively studied. The acylase PvdQ is required for aExpand
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Time Dependent Metabolomics and Transcriptional Analysis of Cannabinoid Biosynthesis in Cannabis sativa var. Bedrobinol and Bediol Grown under Standardized Condition and with Genetic Homogeneity
Cannabis sativa L. is mostly grown under non standardized conditions resulting in high fluctuations of cannabinoid contents. The exact measure of these metabolites is hampered as most of the researchExpand
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Reducing virulence of the human pathogen Burkholderia by altering the substrate specificity of the quorum-quenching acylase PvdQ
Significance Resistance toward commonly used antibiotics is becoming a serious issue in the fight against bacterial pathogens. One promising strategy lies in the interference of bacterial quorumExpand
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Chemistry and Biological Activity of Tetrahydrocannabinol and its Derivatives
Cannabinoids and in particular the main psychoactive Δ9-THC are promising substances forthe development of new drugs and are of high importance in biomedicine and pharmacy. This reviewgives anExpand
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