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Relative importance of transport and alkylation for pancreatic beta-cell toxicity of streptozotocin
Aims/hypothesis. The role of selective uptake and alkylation in the diabetogenic action of streptozotocin was investigated in bioengineered RINm5F insulin-producing cells, with different expressionExpand
Isolation of pectenotoxin-2 from Dinophysis acuta and its conversion to pectenotoxin-2 seco acid, and preliminary assessment of their acute toxicities.
We have developed a simple and effective method for isolating pectenotoxin-2 (PTX-2) from Dinophysis cells collected from a natural bloom. A two-step extraction procedure followed by two columnExpand
Acute toxicity of pinnatoxins E, F and G to mice.
The acute toxicities to mice of pinnatoxins E, F and G, members of the cyclic imine group of phycotoxins, by intraperitoneal injection and/or oral administration, have been determined. TheseExpand
Isolation, structural determination and acute toxicity of pinnatoxins E, F and G.
Pinnatoxins and pteriatoxins are a group of cyclic imine toxins that have hitherto only been isolated from Japanese shellfish. As with other cyclic imine shellfish toxins, pinnatoxins cause rapidExpand
Acute toxicity of gymnodimine to mice.
The acute toxicity of the phycotoxin gymnodimine to female Swiss mice by intraperitoneal injection and by oral administration has been determined. Gymnodimine was highly toxic by injection, the LD50Expand
Toxic dinoflagellates (Dinophyceae) from Rarotonga, Cook Islands.
Dinoflagellate species isolated from the green calcareous seaweed, Halimeda sp. J.V. Lamouroux, growing in Rarotongan lagoons, included Gambierdiscus australes Faust & Chinain, Coolia monotisExpand
Toxicity of thiols and disulphides: involvement of free-radical species.
  • R. Munday
  • Chemistry, Medicine
  • Free radical biology & medicine
  • 1989
Sulphur is essential to life, and thiols and disulphides play essential roles in cellular biochemistry. Such compounds are also widely distributed in the food of man and his domestic animals, andExpand
Thiol-group reactivity, hydrophilicity and stability of alloxan, its reduction products and its N-methyl derivatives and a comparison with ninhydrin.
The diabetogenic agent, alloxan, is a hydrophilic and chemically unstable compound. The logarithm of the octanol/water partition coefficient of alloxan was found to be -1.86; its half-life at pH 7.4Expand
Identification of a benthic microcystin-producing filamentous cyanobacterium (Oscillatoriales) associated with a dog poisoning in New Zealand.
In November 2008 a dog died soon after ingesting benthic "algal" mat material from the Waitaki River, New Zealand. Based on a morphological examination of environmental material, the causativeExpand