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Plant Phenolics: Extraction, Analysis and Their Antioxidant and Anticancer Properties
The anticancer effects of phenolics in-vitro and in- vivo animal models are viewed, including recent human intervention studies, and possible mechanisms of action involving antioxidant and pro-oxidant activity as well as interference with cellular functions are discussed. Expand
The Flipped Classroom: A Course Redesign to Foster Learning and Engagement in a Health Professions School
The authors describe the philosophy and methodology used to redesign the Basic Pharmaceutics II course and outline the research they conducted to investigate the resulting outcomes, concluding that this approach warrants careful consideration as educators aim to enhance learning, improve outcomes, and fully equip students to address 21st-century health care needs. Expand
Elevated copper and oxidative stress in cancer cells as a target for cancer treatment.
This review discusses the targeting of the elevated copper levels and oxidative stress levels in cancer with the aid of a copper chelator d-penicillamine (d-pen) for potential cancer treatment. Expand
Nanoparticle Surface Charges Alter Blood–Brain Barrier Integrity and Permeability
Purpose: The blood–brain barrier (BBB) presents both a physical and electrostatic barrier to limit brain permeation of therapeutics. Previous work has demonstrated that nanoparticles (NPs) overcomeExpand
Pharmacy Student Engagement, Performance, and Perception in a Flipped Satellite Classroom
The flipped pharmacy classroom can enhance the quality of satellite students’ experiences in a basic pharmaceutics course through thoughtful course design, enriched dialogue, and promotion of learner autonomy. Expand
Chitosan and depolymerized chitosan oligomers as condensing carriers for in vivo plasmid delivery.
The combination of strong complex stability and low in vivo expression levels suggest that uptake and/or decomplexation, but not endosomal release, may be the critical rate-limiting steps in the uptake process. Expand
Nanoparticle Technology for Drug Delivery Across the Blood-Brain Barrier
NP technology appears to have significant promise in delivering therapeutic molecules across the blood-brain barrier and primary methods of NP preparation and characterization are described. Expand
Quantitative nanostructure-activity relationship modeling.
The results suggest that QNAR models can be employed for: (i) predicting biological activity profiles of novel nanomaterials, and (ii) prioritizing the design and manufacturing of nanom material toward better and safer products. Expand
Paclitaxel nanoparticles for the potential treatment of brain tumors.
It was hypothesized that PX NPs could mask paclitaxel characteristics and thus limit its binding to p-gp, which consequently would lead to higher brain and tumor cell uptake of the otherwise effluxed drug. Expand
Doxorubicin and paclitaxel-loaded lipid-based nanoparticles overcome multidrug resistance by inhibiting P-glycoprotein and depleting ATP.
Enhanced uptake and prolonged retention of doxorubicin were observed with nanoparticle-based formulations in P-gp-overexpressing cells, and injection of pegylated paclitaxel nanoparticles showed marked anticancer efficacy in nude mice bearing resistant NCI/ADR-RES tumors versus all control groups. Expand